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Studies in mice that investigate underlying mechanisms have shown <jats:italic>Chd8<\/jats:italic> haploinsufficient mice display some trait disruptions that mimic clinical phenotypes, although inconsistencies have been reported in some traits across different models on the same strain background. One source of variation across studies may be the impact of <jats:italic>Chd8<\/jats:italic> haploinsufficiency on maternal\u2010offspring interactions. While differences in maternal care as a function of <jats:italic>Chd8<\/jats:italic> genotype have not been studied directly, a previous study showed that pup survival was reduced when reared by <jats:italic>Chd8<\/jats:italic> heterozygous dams compared with wild\u2010type (WT) dams, suggesting altered maternal care as a function of <jats:italic>Chd8<\/jats:italic> genotype. Through systematic observation of the C57BL\/6 strain, we first determined the impact of <jats:italic>Chd8<\/jats:italic> haploinsufficiency in the offspring on WT maternal care frequencies across preweaning development. We next determined the impact of maternal <jats:italic>Chd8<\/jats:italic> haploinsufficiency on pup care. Compared with litters with all WT offspring, WT dams exhibited less frequent maternal behaviors toward litters consisting of offspring with mixed <jats:italic>Chd8<\/jats:italic> genotypes, particularly during postnatal week 1. Dam <jats:italic>Chd8<\/jats:italic> haploinsufficiency decreased litter survival and increased active maternal care also during postnatal week 1. Determining the impact of <jats:italic>Chd8<\/jats:italic> haploinsufficiency on early life experiences provides an important foundation for interpreting offspring outcomes and determining mechanisms that underlie heterogeneous phenotypes.<\/jats:p>","DOI":"10.1111\/gbb.12892","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T08:14:56Z","timestamp":1711959296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Chd8<\/i> haploinsufficiency impacts rearing experience in C57BL\/6 mice"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-8764","authenticated-orcid":false,"given":"Manal","family":"Tabbaa","sequence":"first","affiliation":[{"name":"Children's Hospital Los Angeles The Saban Research Institute  Los Angeles California USA"},{"name":"Keck School of Medicine of the University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pat","family":"Levitt","sequence":"additional","affiliation":[{"name":"Children's Hospital Los Angeles The Saban Research Institute  Los Angeles California USA"},{"name":"Keck School of Medicine of the University of Southern California  Los Angeles California 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