{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:50:52Z","timestamp":1768017052961,"version":"3.49.0"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Duchenne muscular dystrophy is a severe neuromuscular disorder that is caused by mutations in the <jats:italic>DMD<\/jats:italic> gene, resulting in a disruption of dystrophin production. Next to dystrophin expression in the muscle, different isoforms of the protein are also expressed in the brain and lack of these isoforms leads to cognitive and behavioral deficits in patients. It remains unclear how the loss of the shorter dystrophin isoform Dp140 affects these processes. Using a variety of behavioral tests, we found that <jats:italic>mdx<\/jats:italic> and <jats:italic>mdx<\/jats:italic><jats:sup><jats:italic>4cv<\/jats:italic><\/jats:sup> mice (which lack Dp427 or Dp427\u2009+\u2009Dp140, respectively) exhibit similar deficits in working memory, movement patterns and blood\u2013brain barrier integrity. Neither model showed deficits in spatial learning and memory, learning flexibility, anxiety or spontaneous behavior, nor did we observe differences in aquaporin 4 and glial fibrillary acidic protein. These results indicate that in contrast to Dp427, Dp140 does not play a crucial role in processes of learning, memory and spontaneous behavior.<\/jats:p>","DOI":"10.1111\/gbb.12895","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T09:59:31Z","timestamp":1717581571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Learning, memory and blood\u2013brain barrier pathology in Duchenne muscular dystrophy mice lacking Dp427, or Dp427 and Dp140"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9142-0972","authenticated-orcid":false,"given":"Minou","family":"Verhaeg","sequence":"first","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Adamzek","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davy","family":"van de Vijver","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayleigh","family":"Putker","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Engelbeen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daphne","family":"Wijnbergen","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Overzier","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernst","family":"Suidgeest","sequence":"additional","affiliation":[{"name":"C.J. Gorter MRI Center, Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"van der Weerd","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"},{"name":"C.J. Gorter MRI Center, Department of Radiology Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annemieke","family":"Aartsma\u2010Rus","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0683-8897","authenticated-orcid":false,"given":"Maaike","family":"van Putten","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Leiden University Medical Center  Leiden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103387"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07815-7"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073815570154"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2007.00123.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-8966(06)80008-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807309775"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004703-200612000-00003"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.12922"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.04.004"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/348725a0"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/337076a0"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02265272"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12981-5"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01510-6"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102288"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.5772\/24928"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp320"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8233-5"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.2478\/bjmg-2013-0014"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008803"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229-015-0053-9"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2004.05.004"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2014.079475"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-019-1573-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awn253"},{"key":"e_1_2_12_27_1","first-page":"1041","article-title":"Relationships linking emotional, motor, cognitive and GABAergic dysfunctions in dystrophin\u2010deficient mdx mice","volume":"26","author":"Vaillend C","year":"2017","journal-title":"Hum Mol Genet"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtm.2020.04.025"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049028"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-020-4916-6"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.md.cbf1d33001de80923ce674302cad7925"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1292"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.116"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108563"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.06.011"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.042085.116"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.116.014394"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.11.008"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17726635"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05453"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(01)00041-0"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.03.021"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10216"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12301"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(96)12747-6"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2020.629043"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2017.05.012"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.106.2.274"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03342856"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2003.09.002"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.202101014"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112348"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcsm.12914"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.08.053"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0260com"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.07.055"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2004.08.055"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.12895","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T03:27:22Z","timestamp":1719372442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.12895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":56,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1111\/gbb.12895"],"URL":"https:\/\/doi.org\/10.1111\/gbb.12895","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"2023-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e12895"}}