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However, mechanisms underlying these interactions remain unclear. Male acute and chronic sleep deprivation (SD) mice were used for this study. Mice in the chronic SD group exhibited anxiety\u2010 and depression\u2010like behaviors. We further performed high\u2010throughput genome sequencing and bioinformatics analysis to screen for featured differentially expressed genes (DEGs) in the esophageal tissue. The acute SD group, comprised 25 DEGs including 14 downregulated and 11 upregulated genes. Compared with the acute SD group, more DEGs were present in the chronic SD group, with a total of 169 DEGs, including 88 downregulated and 81 upregulated genes. Some DEGs that were closely related to GERD and associated esophageal diseases were significantly different in the chronic SD group. Quantitative real\u2010time polymerase chain reaction verified the downregulation of Krt4, Krt13, Krt15 and Calml3 and upregulation of Baxl1 and Per3. Notably, these DEGs are involved in biological processes, which might be the pathways of the neuroregulatory mechanisms of DEGs expression.<\/jats:p>","DOI":"10.1111\/gbb.12896","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T19:19:20Z","timestamp":1714072760000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differentially expressed genes of esophageal tissue in male acute and chronic sleep deprivation mice"],"prefix":"10.1111","volume":"23","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gastroenterology First Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Shannxi Clinical Research Center of Digestive Disease (Cancer Devision)  Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurobiology 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