{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:05:32Z","timestamp":1778933132937,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"am","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE\u20101747486"],"award-info":[{"award-number":["DGE\u20101747486"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS106844"],"award-info":[{"award-number":["R01 NS106844"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS120556"],"award-info":[{"award-number":["R01 NS120556"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The gene <jats:italic>FOXP2<\/jats:italic> is well established for a role in human speech and language; far less is known about <jats:italic>FOXP1<\/jats:italic>. However, this related gene has also been implicated in human language development as well as disorders associated with features of autism spectrum disorder (ASD). FOXP1 protein expression has also recently been identified in the cerebellum\u2014a neural structure previously shown to express FOXP2 protein. The current study sought to elucidate the behavioral implications of a conditional knock\u2010out of <jats:italic>Foxp1<\/jats:italic> using an <jats:italic>En1\u2010Cre<\/jats:italic> driver, which is active in the entirety of the cerebellum and a subset of neurons in the midbrain and spinal cord, in mice using a test battery including motor tasks associated with cerebellar dysfunction, as well as communicative and autistic\u2010relevant behaviors. Male and female mice with a conditional knock\u2010out (cKO, <jats:italic>n<\/jats:italic>\u2009=\u200931) and wildtype littermate controls (WT, <jats:italic>n<\/jats:italic>\u2009=\u200934) were assessed for gross and orofacial motor control, motor\u2010coordination learning, locomotion, social behavior, anxiety, auditory processing and expressive vocalizations. Overall results suggest <jats:italic>Foxp1<\/jats:italic> plays a specific role in the development of communicative systems, and phenotypic expression of disruptions may interact with sex. Robust motor deficits associated with Foxp1 protein loss may particularly affect vocalizations based on significant orofacial motor deficits in cKO subjects could also contribute to vocalization anomalies. In summary, the current study provides key insights into the role of <jats:italic>Foxp1<\/jats:italic> in cerebellar function and associated behaviors in mice, with implications for an improved understanding of communicative and motor\u2010based neurodevelopmental disabilities in humans.<\/jats:p>","DOI":"10.1111\/gbb.70001","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T04:29:48Z","timestamp":1729052988000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of cerebellar <scp><i>FOXP1<\/i><\/scp> in the development of motor and communicative behaviors in mice"],"prefix":"10.1111","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6911-3845","authenticated-orcid":false,"given":"R.","family":"Chasse","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences University of Connecticut  Storrs Connecticut USA"},{"name":"Murine Behavioral Neurogenetics Facility and Institute of Brain and Behavioral Sciences University of Connecticut  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"McLeod","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Connecticut  Storrs Connecticut USA"},{"name":"Murine Behavioral Neurogenetics Facility and Institute of Brain and Behavioral Sciences University of Connecticut  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Surian","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Connecticut  Storrs Connecticut USA"},{"name":"Murine Behavioral Neurogenetics Facility and Institute of Brain and Behavioral Sciences University of Connecticut  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. H.","family":"Fitch","sequence":"additional","affiliation":[{"name":"Department of Psychological Sciences University of Connecticut  Storrs Connecticut USA"},{"name":"Murine Behavioral Neurogenetics Facility and Institute of Brain and Behavioral Sciences University of Connecticut  Storrs Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genome Sciences University of Connecticut School of Medicine  Farmington Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439\u2010012\u20101193\u2010z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.375"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.09.017"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36174"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4172\/2165\u20107890.S1\u2010010"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2014.116"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20911"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2009.03.002"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/35097076"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13010127"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abd2827"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1044\/2019_JSLHR\u2010L\u201019\u20100001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.14955"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010021\u201000469\u2010z"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.012"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42388"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1298.032"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_01216"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(02)00935\u20102"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/68547"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.04.005"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.03.029"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01067689"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.07.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0425\u201012.2013"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww327"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.05.007"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014\u20101486"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11689\u2010021\u201009358\u20101"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293\u2010024\u201000621\u20103"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpp.13337"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2022.10.006"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38462"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.04.008"}],"container-title":["Genes, Brain and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.70001","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gbb.70001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T08:21:27Z","timestamp":1729844487000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gbb.70001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/gbb.70001"],"URL":"https:\/\/doi.org\/10.1111\/gbb.70001","archive":["Portico"],"relation":{},"ISSN":["1601-1848","1601-183X"],"issn-type":[{"value":"1601-1848","type":"print"},{"value":"1601-183X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"2023-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70001"}}