{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:13:15Z","timestamp":1789096395675,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007214","name":"Velux Stiftung","doi-asserted-by":"publisher","award":["1216"],"award-info":[{"award-number":["1216"]}],"id":[{"id":"10.13039\/100007214","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human microbiota\u2010associated murine models, using fecal microbiota transplantation (FMT) from human donors, help explore the microbiome's role in diseases like Alzheimer's disease (AD). This study examines how gut bacteria from donors with protective factors against AD influence behavior and brain pathology in an AD mouse model. Female 3xTgAD mice received weekly FMT for 2\u2009months from (i) an 80\u2010year\u2010old AD patient (AD\u2010FMT), (ii) a cognitively healthy 73\u2010year\u2010old with the protective APOEe2 allele (APOEe2\u2010FMT), (iii) a 22\u2010year\u2010old healthy donor (Young\u2010FMT), and (iv) untreated mice (Mice\u2010FMT). Behavioral assessments included novel object recognition (NOR), Y\u2010maze, open\u2010field, and elevated plus maze tests; brain pathology (amyloid and tau), neuroinflammation (in situ autoradiography of the 18\u2009kDa translocator protein in the hippocampus); and gut microbiota were analyzed. APOEe2\u2010FMT improved short\u2010term memory in the NOR test compared to AD\u2010FMT, without significant changes in other behavioral tests. This was associated with increased neuroinflammation in the hippocampus, but no effect was detected on brain amyloidosis and tauopathy. Specific genera, such as\n                    <jats:italic>Parabacteroides<\/jats:italic>\n                    and\n                    <jats:italic>Prevotellaceae_UGC001<\/jats:italic>\n                    , were enriched in the APOEe2\u2010FMT group and associated with neuroinflammation, while genera like\n                    <jats:italic>Desulfovibrio<\/jats:italic>\n                    were reduced and linked to decreased neuroinflammation. Gut microbiota from a donor with a protective factor against AD improved short\u2010term memory and induced neuroinflammation in regions strategic to AD. The association of several genera with neuroinflammation in the APOEe2\u2010FMT group suggests a collegial effect of the transplanted microbiome rather than a single\u2010microbe driver effect. These data support an association between gut bacteria, glial cell activation, and cognitive function in AD.\n                  <\/jats:p>","DOI":"10.1111\/gbb.70012","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T04:16:34Z","timestamp":1736741794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fecal Microbiota Transplantation (\n                    <scp>FMT<\/scp>\n                    ) From a Human at Low Risk for Alzheimer's Disease Improves Short\u2010Term Recognition Memory and Increases Neuroinflammation in a\n                    <scp>3xTg AD<\/scp>\n                    Mouse Model"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-0756","authenticated-orcid":false,"given":"Claire","family":"Chevalier","sequence":"first","affiliation":[{"name":"D\u00e9partement de Readaptation et g\u00e9riatrie University of Geneva  Geneva 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De","family":"Cillis","sequence":"additional","affiliation":[{"name":"Biological Psychiatry Unit IRCCS Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"},{"name":"Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Cattaneo","sequence":"additional","affiliation":[{"name":"Biological Psychiatry Unit IRCCS Centro San Giovanni di Dio Fatebenefratelli  Brescia Italy"},{"name":"Department of Pharmacological and Biomolecular Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Millet","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Psychiatrie University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Readaptation et 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