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Both addiction and the attribution of incentive salience are influenced by environmental and genetic factors. To characterize the genetic contributions to incentive salience attribution, we performed a genome\u2010wide association study (GWAS) in a cohort of 1596 heterogeneous stock (HS) rats. Rats underwent a Pavlovian conditioned approach task that characterized the responses to food\u2010associated stimuli (\u201ccues\u201d). Responses ranged from cue\u2010directed \u201csign\u2010tracking\u201d behavior to food\u2010cup directed \u201cgoal\u2010tracking\u201d behavior (12 measures, SNP heritability: 0.051\u20130.215). Next, rats performed novel operant responses for unrewarded presentations of the cue using the conditioned reinforcement procedure. GWAS identified 14 quantitative trait loci (QTLs) for 11 of the 12 traits across both tasks. Interval sizes of these QTLs varied widely. Seven traits shared a QTL on chromosome 1 that contained a few genes (e.g.,\n                    <jats:italic>Tenm4<\/jats:italic>\n                    ,\n                    <jats:italic>Mir708<\/jats:italic>\n                    ) that have been associated with substance use disorders and other psychiatric disorders in humans. Other candidate genes (e.g.,\n                    <jats:italic>Wnt11<\/jats:italic>\n                    ,\n                    <jats:italic>Pak1<\/jats:italic>\n                    ) in this region had coding variants and expression\u2010QTLs in mesocorticolimbic regions of the brain. We also conducted a Phenome\u2010Wide Association Study (PheWAS) on addiction\u2010related behaviors in HS rats and found that the QTL on chromosome 1 was also associated with nicotine self\u2010administration in a separate cohort of HS rats. These results provide a starting point for the molecular genetic dissection of incentive motivational processes and provide further support for a relationship between the attribution of incentive salience and drug abuse\u2010related traits.\n                  <\/jats:p>","DOI":"10.1111\/gbb.70018","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:15:58Z","timestamp":1741738558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Genetic Loci Influencing Cue\u2010Reactivity in Heterogeneous Stock Rats"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6641-237X","authenticated-orcid":false,"given":"Christopher P.","family":"King","sequence":"first","affiliation":[{"name":"Department of Psychology University at Buffalo  Buffalo New York USA"},{"name":"Clinical and Research Institute on Addictions  Buffalo New York 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