{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:32:44Z","timestamp":1753878764194,"version":"3.41.2"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004350","name":"Studienstiftung des Deutschen Volkes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004350","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Alcohol addiction is a widespread disease, and the exact causes and consequences are still not fully determined. Neurotransmitters and neuronal circuits are not only the target structure of alcohol and responsible for its direct effects but also play a central role in the development of addiction. A gene that has been linked to alcohol use disorder in recent studies is the <jats:italic>ganglioside\u2010induced differentiation\u2010associated protein 1 (GDAP1)<\/jats:italic> gene. The present study focuses on the hippocampus, a brain region particularly vulnerable to alcohol and rich in <jats:italic>Gdap1<\/jats:italic> gene expression. Using an established drinking model, alcohol drinking behavior was induced in adult male Long Evans rats. After 6\u2009weeks of voluntary alcohol intake, followed by 2\u2009weeks of deprivation, the animals were divided into two groups based on the alcohol deprivation effect (ADE). <jats:italic>Gdap1<\/jats:italic> gene expression was measured with real\u2010time PCR in the hippocampus. Results reveal significantly decreased mRNA expression in the high ADE group compared to the low ADE group. This decrease was specifically detected within the cornu ammonis 3 (CA3) region. <jats:italic>Gdap1<\/jats:italic> expression in this region also negatively correlated with ADE in all animals. Taken together, results indicate that <jats:italic>Gdap1<\/jats:italic> might not only be associated with alcohol consumption but might even play a role in alcohol dependence.<\/jats:p>","DOI":"10.1111\/gbb.70022","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T05:05:46Z","timestamp":1745039146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expression of <scp>GDAP1<\/scp> Gene Correlates With Alcohol Deprivation Effect"],"prefix":"10.1111","volume":"24","author":[{"given":"Rona","family":"Yarimay","sequence":"first","affiliation":[{"name":"Division of Experimental and Molecular Psychiatry, Department of Psychiatry, Psychotherapy and Preventive Medicine LWL University Hospital, Ruhr\u2010University Bochum  Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik K. 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