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impulsive personality traits via the UPPS\u2010P scales, is a key transdiagnostic construct across psychiatric disorders. Recent genome\u2010wide association studies (GWAS) have studied the genetic basis of impulsivity in adults, but it remains unclear how similar the genetic architecture of DD is in children. The present study conducted GWAS of DD and impulsivity traits in 5548 children (ages 9\u201310\u2009years old) of genetically inferred European ancestry from the Adolescent Brain Cognitive Development (ABCD) Study. Heritability estimates for DD (<jats:italic>h<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.20, S.E.\u2009=\u20090.10) and UPPS\u2010P subscales (<jats:italic>h<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090.08\u20130.11\u2009S.E.\u2009=\u20090.05) were comparable to adult estimates. Genetic correlations between adult and child impulsivity were modest (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.28\u20130.46), with positive urgency showing the strongest correlation (<jats:italic>r<\/jats:italic><jats:sub>g<\/jats:sub>\u2009=\u20090.83). While no genome\u2010wide significant associations were identified, the top associated variants were mapped to genes previously linked to smoking initiation (rs3820908; <jats:italic>p<\/jats:italic>\u2009=\u20096.5\u2009\u00d7\u200910<jats:sup>\u22128<\/jats:sup>) and UPPS\u2010P Lack of Premeditation (rs17292179; <jats:italic>p<\/jats:italic>\u2009=\u20094.2\u2009\u00d7\u200910<jats:sup>\u22127<\/jats:sup>). Polygenic score (PGS) associations were used to compare the genetic signals in children with those reported in adults. Adult PGSs for DD and positive and negative urgency indicators explained small but significant variance in the respective child impulsivity phenotypes (0.36%\u20130.44%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20097.5\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup>). Additionally, UPPS\u2010P indices were broadly associated with PGSs derived from adult externalizing (0.42%\u20131.02%) and ADHD (0.23%\u20130.79%). This first GWAS of impulsivity in children offers a developmentally informed comparison of genetic influences, revealing both similarities and differences by developmental stage.<\/jats:p>","DOI":"10.1111\/gbb.70033","type":"journal-article","created":{"date-parts":[[2025,8,23]],"date-time":"2025-08-23T12:35:14Z","timestamp":1755952514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genome\u2010Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study"],"prefix":"10.1111","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4212-2607","authenticated-orcid":false,"given":"Wei Q.","family":"Deng","sequence":"first","affiliation":[{"name":"Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5403-9531","authenticated-orcid":false,"given":"Kyla L.","family":"Belisario","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6137-5699","authenticated-orcid":false,"given":"Sandra","family":"Sanchez\u2010Roige","sequence":"additional","affiliation":[{"name":"Department of Psychiatry UCSD  La Jolla California USA"},{"name":"Division of Genetic Medicine Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Institute for Genomic Medicine, UCSD  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham A.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry UCSD  La Jolla California USA"},{"name":"Institute for Genomic Medicine, UCSD  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8695-1071","authenticated-orcid":false,"given":"James","family":"MacKillop","sequence":"additional","affiliation":[{"name":"Peter Boris Centre for Addictions Research, St. Joseph's Healthcare Hamilton  Hamilton Ontario Canada"},{"name":"Department of Psychiatry and Behavioural Neurosciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1037\/PAS0000111"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1010076108"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010011\u20102229\u20100"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jeab.4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/NN1583"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9391.001.0001"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/GBB.12848"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/S00213\u2010016\u20104372\u20100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13977"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.11.003"},{"key":"e_1_2_8_12_1","unstructured":"J. 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