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ASD has a male\u2010bias prevalence, but several studies have proposed that female prevalence may be underestimated due to different symptomatic expression compared with males. However, it is unclear whether this is related to actual different pathological features or to greater masking abilities in females. Studies on\n                    <jats:italic>Scn2a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice, a model of\n                    <jats:italic>SCN2A<\/jats:italic>\n                    haploinsufficiency and ASD, have shown an age\u2010dependent ASD\u2010like phenotype attenuated at adulthood in males. However, little is known about the behavioral features of\n                    <jats:italic>Scn2a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    female mice. We performed a battery of behavioral tests that are relevant for assessing ASD\u2010like features, investigating juvenile and adult\n                    <jats:italic>Scn2a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    female mice. Our results demonstrate that female\n                    <jats:italic>Scn2a<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>+\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibit an overall milder phenotype than males, showing increased risk\u2010taking in juveniles, hyper\u2010reactivity to cold stimuli, and mild memory impairments in adults, abnormally increased sociability, and altered decision\u2010making related behaviors in both juveniles and adults. Thus, this aligns with the male\u2010biased prevalence of ASD and supports the existence of sex\u2010specific phenotypic differences, potentially arising from distinct underlying pathophysiological mechanisms. Both sexes should be investigated in studies of mouse models of ASD.\n                  <\/jats:p>","DOI":"10.1111\/gbb.70034","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T04:32:31Z","timestamp":1756701151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sex\u2010Specific Behavioral Features of Juvenile and Adult Haploinsufficient\n                    <i>\n                      Scn2a\n                      <sup>+\/\u2212<\/sup>\n                    <\/i>\n                    Female Mice, Model of Autism Spectrum Disorder"],"prefix":"10.1111","volume":"24","author":[{"given":"Wendy","family":"Marcantonio","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te D'azur  Valbonne \u2010 Sophia Antipolis France"},{"name":"CNRS, UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne \u2010 Sophia Antipolis France"},{"name":"Inserm U1323  Valbonne \u2010 Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Simonti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te D'azur  Valbonne \u2010 Sophia Antipolis France"},{"name":"CNRS, UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne \u2010 Sophia Antipolis France"},{"name":"Inserm U1323  Valbonne \u2010 Sophia Antipolis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"L\u00e9na","sequence":"additional","affiliation":[{"name":"Universit\u00e9 C\u00f4te D'azur  Valbonne \u2010 Sophia Antipolis France"},{"name":"CNRS, UMR 7275, Institute of Molecular and Cellular Pharmacology (IPMC)  Valbonne \u2010 Sophia Antipolis France"},{"name":"Inserm U1323  Valbonne \u2010 Sophia Antipolis 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