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Genome\u2010wide association studies (GWASs) have identified multiple cognitive function\u2010associated loci, primarily in the European population. However, those in Asian populations, particularly in individuals of Japanese ancestry, remain limited. Hence, this GWAS aimed to identify cognitive function\u2010associated genetic loci in elderly individuals of Japanese ancestry. Herein, 2571 elderly participants from the Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study were included. Their cognitive function was assessed using the Japanese version of the Mini\u2010Mental State Examination (MMSE), and both binary and continuous MMSE scores were analysed. Genotyping was performed using the Affymetrix Axiom Japonica Array v2, and imputation was conducted with 3.5KJPNv2 and 1KGP3. Statistical analyses were performed using FastGWA\u2010GLMM and FastGWA for binary and continuous MMSE scores, respectively. Although no genome\u2010wide significant loci were identified using binary MMSE values, the following two were detected using continuous MMSE values: rs77877360 (20p12.1) near\n                    <jats:italic>BANF2<\/jats:italic>\n                    and\n                    <jats:italic>SNX5<\/jats:italic>\n                    and rs9460729 (6p22.3) near\n                    <jats:italic>PRL<\/jats:italic>\n                    and\n                    <jats:italic>HDGFL1<\/jats:italic>\n                    . Additionally, functional annotation suggested the involvement of these loci in pathways related to cognitive function, including chromatin structure regulation, neuroinflammation, and iron metabolism. Notably,\n                    <jats:italic>SNX5<\/jats:italic>\n                    , identified through chromatin\u2010interaction mapping, has been implicated in neurodegenerative processes, particularly in Parkinson's disease. The findings of this study provide preliminary genome\u2010wide evidence suggesting a genetic predisposition to impaired cognitive function in elderly Japanese individuals.\n                  <\/jats:p>","DOI":"10.1111\/gbb.70038","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T12:26:24Z","timestamp":1760790384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genome\u2010Wide Association Study of Cognitive Function in Population\u2010Based Cohorts in Japan: The Tohoku Medical Megabank Brain Magnetic Resonance Imaging Study"],"prefix":"10.1111","volume":"24","author":[{"given":"Genki","family":"Shinoda","sequence":"first","affiliation":[{"name":"Tohoku Medical Megabank Organization Tohoku University  Sendai Japan"},{"name":"Graduate School of Medicine Tohoku University  Sendai 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