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While genetic and sex\u2010specific effects have been reported in many neurodegenerative and psychiatric illnesses, these factors may also alter baseline neuroanatomical features of mice. This raises the question of whether the observed changes are related to the disease being studied (i.e., pathological differences) or if there are baseline strain or sex differences that may predispose animals to different responses. Over the past decade, tremendous effort has been made to map neural architecture at various scales; however, the complex relationships, including identifying genetic and sex\u2010specific differences in brain structure and function, remain understudied. To bridge this gap, we used C57BL\/6J and DBA\/2J mice, two of the most widely used inbred mouse strains in neuroscience research, to investigate strain and sex\u2010specific features of the brain connectome in awake animals using magnetic resonance imaging (MRI). By combining resting\u2010state functional MRI and diffusion MRI, we found that the motor, sensory, limbic, and salience networks exhibit significant differences in both functional and structural domains between C57BL\/6J and DBA\/2J mice. Further, functional and structural properties of the brain were significantly correlated in both strains. Our results underscore the importance of considering these baseline differences when interpreting brain\u2010behavior interactions in mouse models of human disorders.<\/jats:p>","DOI":"10.1111\/gbb.70060","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T15:59:31Z","timestamp":1782489571000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Dissecting the Strain and Sex Specific Connectome Signatures of Unanesthetized\n                    <scp>C57BL<\/scp>\n                    \/\n                    <scp>6J<\/scp>\n                    and\n                    <scp>DBA<\/scp>\n                    \/\n                    <scp>2J<\/scp>\n                    Mice Using Magnetic Resonance Imaging"],"prefix":"10.1111","volume":"25","author":[{"given":"Tanzil M.","family":"Arefin","sequence":"first","affiliation":[{"name":"Huck Institutes of Life Science, The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Biomedical Engineering The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Center for Neurotechnology in Mental Health Research The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Neuroscience University of Rochester Medical Center  Rochester New York USA"},{"name":"Center for Advanced Brain Imaging and Neurophysiology, University of Rochester Medical Center  Rochester USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayreddin Said","family":"\u00dcnsal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Electrical and Electronics Engineering Abdullah Gul University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neuberger","sequence":"additional","affiliation":[{"name":"Huck Institutes of Life Science, The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Biomedical Engineering The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Huck Institutes of Life Science, The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Department of Biomedical Engineering The Pennsylvania State University  University Park Pennsylvania USA"},{"name":"Center for Neurotechnology in Mental Health Research The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen M.","family":"Kamens","sequence":"additional","affiliation":[{"name":"Department of Biobehavioral Health The Pennsylvania State University  University Park Pennsylvania 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