{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:08:07Z","timestamp":1788851287796,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Genes Brain and Behavior"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Glucocorticoid signalling plays a central role in the processing of traumatic memories and contributes to adaptive and pathological responses to stress, with dysregulation frequently reported in trauma\u2010related conditions such as post\u2010traumatic stress disorder (PTSD). A key stage in trauma memory formation is the early consolidation window, during which aversive experiences are stabilised into long\u2010term memory through protein synthesis and activity\u2010dependent gene expression. To investigate how glucocorticoid levels during trauma exposure shape this process, we examined the behavioural and molecular consequences of acute and chronic corticosterone elevation, the rodent analogue of cortisol. Adult male mice received either repeated corticosterone injections for 5\u2009days prior to fear conditioning (FC) or vehicle injections for 5\u2009days followed by a single corticosterone injection immediately before FC. Two hours after FC, we quantified expression of genes encoding mineralocorticoid receptors (\n                    <jats:italic>Nr3c2<\/jats:italic>\n                    , MR), glucocorticoid receptors (\n                    <jats:italic>Nr3c1<\/jats:italic>\n                    , GR), and FK506\u2010binding protein 5 (\n                    <jats:italic>Fkbp5<\/jats:italic>\n                    ) in the amygdala, hippocampus, and anterior cingulate cortex (ACC). Trauma memory was assessed 24\u2009h later by measuring freezing and exploratory behaviour to conditioned cues in separate experimental cohorts. Chronic corticosterone exposure was associated with attenuated conditioning\u2010related behavioural responses, whereas acute corticosterone did not alter these responses. These effects were accompanied by region\u2010specific alterations in glucocorticoid\u2010signalling gene expression, most notably coordinated regulation of hippocampal and ACC\n                    <jats:italic>Nr3c2<\/jats:italic>\n                    following FC. We propose that this regional\n                    <jats:italic>Nr3c2<\/jats:italic>\n                    transcriptional signature represents an early molecular adaptation to prolonged glucocorticoid exposure that may alter hippocampal\u2013prefrontal communication during trauma\u2010memory formation.\n                  <\/jats:p>","DOI":"10.1111\/gbb.70067","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:24:16Z","timestamp":1788848656000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chronic Pre\u2010Trauma Corticosterone Attenuates Trauma Memory Formation and Alters Gene Expression in Glucocorticoid Signalling Pathways"],"prefix":"10.1111","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1719-3717","authenticated-orcid":false,"given":"Gia","family":"Kutelia","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"},{"name":"Department of Biocybernetic Systems Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2730-5247","authenticated-orcid":false,"given":"Zurab","family":"Kuchukashvili","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rusiko","family":"Ansiani","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roza","family":"Bukia","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"},{"name":"Department of Biocybernetic Systems Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manana","family":"Chikovani","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Butsiko","family":"Chkhartishvili","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3973-5322","authenticated-orcid":false,"given":"Nanuli","family":"Doreulee","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Exact and Natural Sciences Ivane Javakhishvili Tbilisi State University  Tbilisi 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