{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:13:30Z","timestamp":1790813610012,"version":"4.1.0"},"reference-count":103,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Global Change Biology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The integrity of coral reefs worldwide is jeopardized by ocean acidification (OA). Most studies conducted so far have focused on the vulnerability to OA of corals inhabiting shallow reefs while nothing is currently known about the response of mesophotic scleractinian corals. In this study, we assessed the susceptibility to OA of corals, together with their algal partners, inhabiting a wide depth range. We exposed fragments of the depth generalist coral <jats:italic>Stylophora pistillata<\/jats:italic> collected from either 5 or 45\u00a0m to simulated future OA conditions, and assessed key molecular, physiological and photosynthetic processes influenced by the lowered pH. Our comparative analysis reveals that mesophotic and shallow <jats:italic>S<\/jats:italic>. <jats:italic>pistillata<\/jats:italic> corals are genetically distinct and possess different symbiont types. Under the exposure to acidification conditions, we observed a 50% drop of metabolic rate in shallow corals, whereas mesophotic corals were able to maintain unaltered metabolic rates. Overall, our gene expression and physiological analyses show that mesophotic corals possess a greater capacity to cope with the effects of OA compared to their shallow counterparts. Such capability stems from physiological characteristics (i.e., biomass and lipids energetics), a greater capacity to regulate cellular acid\u2013base parameters, and a higher baseline expression of cell adhesion and extracellular matrix genes. Moreover, our gene expression analysis suggests that the enhanced symbiont photochemical efficiency under high <jats:italic>p<\/jats:italic>CO<jats:sub>2<\/jats:sub> levels could prevent acidosis of the host cells and it could support a greater translocation of photosynthates, increasing the energy pool available to the host. With this work, we provide new insights on the response to OA of corals living at mesophotic depths. Our investigation discloses key genetic and physiological traits underlying the potential for corals to cope with future OA conditions.<\/jats:p>","DOI":"10.1111\/gcb.15812","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T13:47:10Z","timestamp":1627307230000},"page":"5276-5294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic and physiological traits conferring tolerance to ocean acidification in mesophotic corals"],"prefix":"10.1111","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-4758","authenticated-orcid":false,"given":"Federica","family":"Scucchia","sequence":"first","affiliation":[{"name":"Department of Marine Biology Leon H. Charney school of Marine Sciences University of Haifa Haifa Israel"},{"name":"The Interuniversity Institute of Marine Sciences Eilat Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Marine Biology Leon H. Charney school of Marine Sciences University of Haifa Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2322-3269","authenticated-orcid":false,"given":"Hollie M.","family":"Putnam","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Rhode Island Kingston Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7298-290X","authenticated-orcid":false,"given":"Tali","family":"Mass","sequence":"additional","affiliation":[{"name":"Department of Marine Biology Leon H. Charney school of Marine Sciences University of Haifa Haifa Israel"},{"name":"Morris Kahn Marine Research Station The Leon H. Charney School of Marine Sciences University of Haifa Sdot Yam Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2020.600836"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-8-126"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804478105"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413483112"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-294X.2010.04574.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ece3.5712"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10126-011-9363-x"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsbl.2018.0777"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00338-009-0581-x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.2011.56.3.0927"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.063"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3176"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/425365a"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.5670\/oceanog.2009.102"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fsv267"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.2013.58.1.0388"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.2014.59.3.1081"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-0149(87)90021-5"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts635"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1301419110"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.080549"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.2011.56.6.2402"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2016.00195"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.14038"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128697"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1137094"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2018.00174"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0459-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jembe.2014.03.015"},{"issue":"11","key":"e_1_2_10_32_1","first-page":"1963","article-title":"Intracellular pH and its response to CO2\u2010driven seawater acidification in symbiotic versus non\u2010symbiotic coral cells","volume":"217","author":"Gibbin E. M.","year":"2014","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsl.2010.04.044"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tree.2019.04.010"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ecy.2232"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/maec.12291"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/mec.15050"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04565"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aba9958"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.58.030196.002543"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46412-4"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00338-016-1404-5"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18371"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2017.00158"},{"key":"e_1_2_10_45_1","volume-title":"IPCC special report on the ocean and cryosphere in a changing climate","author":"IPCC","year":"2019"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jembe.2011.10.008"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-7567-0_2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0034659"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.13833"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gca.2010.05.023"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.12179"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90614-8"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ecolsys-110617-062423"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1890\/09-0313.1"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps11072"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aar8028"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92735-0"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1461-0248.2001.00203.x"},{"key":"e_1_2_10_60_1","article-title":"Molecular and skeletal fingerprints of scleractinian coral biomineralization: From the sea surface to mesophotic depths","author":"Malik A.","year":"2020","journal-title":"Acta Biomaterialia"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2012.58"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.2307\/1933661"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.14806\/ej.17.1.200"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2020.566663"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3354\/meps334093"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/nclimate1473"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.107524.110"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.4319\/lo.1973.18.6.0897"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1712806115"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1902126116"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/icesjms\/fsv127"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.258.6.C967"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1204794"},{"key":"e_1_2_10_74_1","volume-title":"MS Excel program developed for CO2 system calculations","author":"Pierrot D. E.","year":"2012"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/0198-0149(82)90087-5"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92735-0_50"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.199.8.1801"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11099-008-0019-7"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052212"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12065-0"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075049"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17639"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2021.0328"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21619"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0801328105"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2015.02.018"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00338-018-1733-7"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00338-012-0996-7"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1111\/gcb.15372"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029535"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.9.8.2287"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0123394"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.5194\/bg-10-3997-2013"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10584-011-0148-z"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1216153110"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058652"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17484-x"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.170683"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1029\/2018MS001452"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1558-5646.1984.tb05657.x"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.5194\/bg-10-1647-2013"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2061"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msy194"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2015.00004"}],"container-title":["Global Change Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.15812","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/gcb.15812","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/gcb.15812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T06:58:38Z","timestamp":1693292318000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/gcb.15812"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,2]]},"references-count":103,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1111\/gcb.15812"],"URL":"https:\/\/doi.org\/10.1111\/gcb.15812","archive":["Portico"],"relation":{},"ISSN":["1354-1013","1365-2486"],"issn-type":[{"value":"1354-1013","type":"print"},{"value":"1365-2486","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,2]]},"assertion":[{"value":"2021-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}