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Accelerated ocean acidification from elevated CO<jats:sub>2<\/jats:sub> threatens the ability of crabs to detect and respond to important olfactory\u2010related cues. Here, we demonstrate that the ecologically and economically important Dungeness crab (<jats:italic>Metacarcinus magister<\/jats:italic>) exhibits reduced olfactory\u2010related antennular flicking responses to a food cue when exposed to near\u2010future CO<jats:sub>2<\/jats:sub> levels, adding to the growing body of evidence of impaired crab behaviour. Underlying this altered behaviour, we find that crabs have lower olfactory nerve sensitivities (twofold reduction in antennular nerve activity) in response to a food cue when exposed to elevated CO<jats:sub>2<\/jats:sub>. This suggests that near\u2010future CO<jats:sub>2<\/jats:sub> levels will impact the threshold of detection of food by crabs. We also show that lower olfactory nerve sensitivity in elevated CO<jats:sub>2<\/jats:sub> is accompanied by a decrease in the olfactory sensory neuron (OSN) expression of a principal chemosensory receptor protein, ionotropic receptor 25a (IR25a) which is fundamental for odorant coding and olfactory signalling cascades. The OSNs also exhibit morphological changes in the form of decreased surface areas of their somata. This study provides the first evidence of the effects of high CO<jats:sub>2<\/jats:sub> levels at multiple levels of biological organization in marine crabs, linking physiological and cellular changes with whole animal behavioural responses.<\/jats:p>","DOI":"10.1111\/gcb.16738","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T18:35:08Z","timestamp":1683743708000},"page":"4126-4139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Ocean acidification alters foraging behaviour in Dungeness crab through impairment of the olfactory pathway"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-4408","authenticated-orcid":false,"given":"Andrea","family":"Durant","sequence":"first","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa","family":"Khodikian","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4730-4960","authenticated-orcid":false,"given":"Cosima S.","family":"Porteus","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences University of Toronto Scarborough  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(85)90122-5"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.136610"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1029\/2021av000456"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.118549"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2015.00009"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1029\/2009GL040999"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.014894"},{"key":"e_1_2_10_9_1","first-page":"379","volume-title":"Climate change 2022: Impacts, adaptation and vulnerability","author":"Cooley S.","year":"2022"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060551"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jembe.2011.12.005"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jembe.2011.11.013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anbehav.2011.05.030"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2307\/1542280"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/713537"},{"key":"e_1_2_10_16_1","first-page":"191","volume-title":"Guide to best practices for ocean CO2 measurements","author":"Dickson A. 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