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UVBR damages DNA and is an important modulator of immune function and disease susceptibility in humans and other vertebrates. The effect of UVBR on invertebrate immune function is largely unknown, but UVBR together with ultraviolet\u2010A radiation impairs an insect immune response that utilizes melanin, a pigment that also protects against UVBR\u2010induced DNA damage. If UVBR weakens insect immunity, then it may make insect disease vectors more susceptible to infection with pathogens of socioeconomic and public health importance. In the tropics, where UVBR is predicted to increase, the mosquito\u2010borne dengue virus (DENV), is prevalent and a growing threat to humans. We therefore examined the effect of UVBR on the mosquito <jats:italic>Aedes aegypti<\/jats:italic>, the primary vector for DENV, to better understand the potential implications of increased tropical UVBR for mosquito\u2010borne disease risk. We found that exposure to a UVBR dose that caused significant larval mortality approximately doubled the probability that surviving females would become infected with DENV, despite this UVBR dose having no effect on the expression of an effector gene involved in antiviral immunity. We also found that females exposed to a lower UVBR dose were more likely to have low fecundity even though this UVBR dose had no effect on larval size or activity, pupal cuticular melanin content, or adult mass, metabolic rate, or flight capacity. We conclude that future increases in tropical UVBR associated with anthropogenic global change may have the benefit of reducing mosquito\u2010borne disease risk for humans by reducing mosquito fitness, but this benefit may be eroded if it also makes mosquitoes more likely to be infected with deadly pathogens.<\/jats:p>","DOI":"10.1111\/gcb.16906","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T08:14:23Z","timestamp":1691655263000},"page":"5540-5551","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Exposure to ultraviolet\u2010B radiation increases the susceptibility of mosquitoes to infection with dengue virus"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4236-2494","authenticated-orcid":false,"given":"Lesley A.","family":"Alton","sequence":"first","affiliation":[{"name":"Centre for Geometric Biology Monash University  Melbourne Victoria Australia"},{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Novelo","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"},{"name":"Department of Entomology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1618-5308","authenticated-orcid":false,"given":"Julian E.","family":"Beaman","sequence":"additional","affiliation":[{"name":"Centre for Geometric Biology Monash University  Melbourne Victoria Australia"},{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6158-7752","authenticated-orcid":false,"given":"Pieter A.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Centre for Geometric Biology Monash University  Melbourne Victoria Australia"},{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice L.","family":"Bywater","sequence":"additional","affiliation":[{"name":"Centre for Geometric Biology Monash University  Melbourne Victoria Australia"},{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Kerton","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Centre for Geometric Biology Monash University  Melbourne Victoria Australia"},{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra","family":"Koh","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7973-088X","authenticated-orcid":false,"given":"Elizabeth A.","family":"McGraw","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Monash University  Melbourne Victoria Australia"},{"name":"Department of Biology, Center for Infectious Disease Dynamics, The Huck Institutes of the Life Sciences The Pennsylvania State University  University Park Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1239401"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1365\u20102435.13663"},{"key":"e_1_2_9_4_1","doi-asserted-by":"crossref","unstructured":"Alton L. 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