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Although a large body of literature describes changes in biomass in response to these drivers, the biochemical mechanisms driving these shifts remain unclear. This study investigated the long\u2010term response of the marine diatom\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Thalassiosira weissflogii<\/jats:italic>\n                    <\/jats:styled-content>\n                    to high CO\n                    <jats:sub>2<\/jats:sub>\n                    , warming, and their combinations (3.5\u2009years, ~2000 generations) and examined how these changes affect its metabolomic profile and influence a primary consumer (a clam), using metabolomics and biochemical analysis. Our results reveal significant metabolomic shifts in diatoms after 2000 generations, including increased glutaric acid and gluconolactone, reflecting enhanced carbon metabolism and biosynthesis. Warming induces higher pyruvic acid levels and decreased propionic acid, indicating metabolic reprogramming to maintain energy production and redox balance. These biochemical alterations cascade to consumers, creating alterations in metabolite profiles and affecting their energy metabolism, with implications for similar effects on other consumers. These findings highlight the critical role of metabolite\u2010mediated interactions in shaping food web dynamics under global change. By integrating molecular and ecological perspectives, our study advances the understanding of how environmental drivers affect ecosystem processes such as nutrient cycling, energy flow, and trophic efficiency. We emphasized the need to incorporate metabolomic data into ecological models to predict ecosystem responses to global change.\n                  <\/jats:p>","DOI":"10.1111\/gcb.70343","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T05:31:30Z","timestamp":1751952690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Metabolite\u2010Mediated Trophic Interactions: Long\u2010Term Responses of\n                    <i>Thalassiosira weissflogii<\/i>\n                    to High\n                    <scp>\n                      CO\n                      <sub>2<\/sub>\n                    <\/scp>\n                    and Warming Have Cascading Effects on Consumer Metabolism"],"prefix":"10.1111","volume":"31","author":[{"given":"Fenghuang","family":"Wu","sequence":"first","affiliation":[{"name":"School of Environmental Science and Engineering Guangzhou University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Environmental Science and Engineering Guangzhou University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Beardall","sequence":"additional","affiliation":[{"name":"School of Biological Sciences Monash University  Clayton Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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