{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:57:48Z","timestamp":1754600268997},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T00:00:00Z","timestamp":1353888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This longitudinal study evaluated the relationship between low renal function and tooth loss in elderly subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Subjects comprised 406 female subjects (55\u201374\u00a0years old) who agreed to participate in a baseline examination and a follow\u2010up examination after 5\u00a0years. Serum cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels were used to assess renal function. Multiple logistic regression analysis was used to evaluate the relationship between tooth loss and change in serum cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels over 5\u00a0years. Tooth loss over 5\u00a0years (0: no, 1: yes) was used as the dependent variable. Seven variables were used as independent variables, including change in serum cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels over 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results of multiple logistic regression analysis showed that cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> change over 5\u00a0years, age, number of remaining teeth at baseline, number of sites with \u22654\u00a0mm clinical attachment level at baseline and serum 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> levels at baseline were significantly associated with tooth loss. The odds ratio for tooth loss with cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> change over 5\u00a0years was 7.70 (<jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.029).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study indicates a relationship between serum cystatin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> levels and number of missing teeth, and thus suggests that low renal function is associated with tooth loss.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12015","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T10:28:53Z","timestamp":1353925733000},"page":"111-116","source":"Crossref","is-referenced-by-count":8,"title":["Association between low renal function and tooth loss over 5\u00a0years"],"prefix":"10.1111","volume":"31","author":[{"given":"Akihiro","family":"Yoshihara","sequence":"first","affiliation":[{"name":"Department of Oral Health and Welfare Graduate School of Medical and Dental Sciences, Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Iwasaki","sequence":"additional","affiliation":[{"name":"Department of Oral Health Science Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Oral Health Science Graduate School of Medical and Dental Sciences Niigata University Niigata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Community Preventive Medicine Graduate School of Medical and Dental Sciences, Niigata University Niigata 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