{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T03:09:15Z","timestamp":1771470555572,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T00:00:00Z","timestamp":1417046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Melanoma of the skin is characterised by a high metastatic potential, but reports of metastasis to the tongue are rare. We report a case of skin melanoma with metastasis to the lymph nodes, tongue and brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This report highlights the clinical and histological features of oral metastatic melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p>A 72\u2010year\u2010old man was seen with a nodule on the tongue. The differential diagnosis included salivary gland tumour, lymphoma and metastatic melanoma. His medical history revealed treatment for melanoma in the periumbilical region and micrometastases in the inguinal lymph nodes. An incisional biopsy was obtained and histological analysis showed the presence of a solid, epithelioid malignant tumour of monotonous appearance infiltrating the skeletal musculature. Immunohistochemistry showed reactivity of neoplastic cells to anti\u2010<jats:styled-content style=\"fixed-case\">HMB<\/jats:styled-content>45, anti\u2010melan A and anti\u2010S100 antibodies and negativity for anti\u2010<jats:styled-content style=\"fixed-case\">PAN<\/jats:styled-content> cytokeratin, confirming the diagnosis of metastatic melanoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present findings highlight the importance of a complete medical evaluation of the patient by anamnesis to identify possible oral repercussions of primary diseases in other organs and\/or systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12032","type":"journal-article","created":{"date-parts":[[2014,11,27]],"date-time":"2014-11-27T06:59:18Z","timestamp":1417071558000},"page":"314-319","source":"Crossref","is-referenced-by-count":5,"title":["Metastatic melanoma of the tongue: a case report with immunohistochemical profile"],"prefix":"10.1111","volume":"31","author":[{"given":"M\u00f4nica Ghislaine O.","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ. Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciene R.","family":"Chagas","sequence":"additional","affiliation":[{"name":"Nursing Course Health Sciences School Universidade do Vale do Para\u00edba S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasmin R.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ. Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz A. G.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ. Estadual Paulista S\u00e3o Jos\u00e9 dos Campos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo D.","family":"Coletta","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnosis Oral Pathology Division Piracicaba Dental School University of Campinas Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janete D.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Department of Biosciences and Oral Diagnosis S\u00e3o Jos\u00e9 dos Campos Dental School UNESP \u2013 Univ. 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