{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T16:22:35Z","timestamp":1769876555597,"version":"3.49.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T00:00:00Z","timestamp":1375920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Massive osteolysis (<jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>orham\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tout syndrome) is a rare condition of unknown etiology that is thought to result from a localized endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. Osteolysis of the jaws has been reported in association with infection, cysts, neoplasia, and metabolic, endocrine, or hematologic abnormalities. Rare cases of idiopathic osteolysis have also been recorded. A detailed review from various peer reviewed journals has been discussed in this article.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To discuss the demographic distribution and possibilities of pathogenesis of <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>orham\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tout syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and method<\/jats:title><jats:p>A case report of vanishing bone disease of the mandible in a 60\u00a0year old female patient has been discussed. A detail review of literature highlighting the demographic distribution and pathogenesis of vanishing bone disease has been made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty eight percentages of these lesions appear in older individuals with a slight male predilection. 68.6% of the oro\u2010facial massive osteolysis occurs in mandible has been reported. Variable etiopathogenesis such as vascular proliferation, increased levels of circulating cytokines and circulatory disturbances have been associated with this disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>orham\u2013<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tout syndrome though rarely seen in the facial skeleton, it is important to consider it in the differential diagnosis of osteolytic lesions of the jaws.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12054","type":"journal-article","created":{"date-parts":[[2013,8,8]],"date-time":"2013-08-08T07:17:08Z","timestamp":1375946228000},"page":"296-302","source":"Crossref","is-referenced-by-count":8,"title":["Vanishing bone disease of the mandible \u2013 a case report"],"prefix":"10.1111","volume":"30","author":[{"given":"Mysore L.","family":"Asha","sequence":"first","affiliation":[{"name":"Department of Oral Medicine and Radiology Sri Hasanamba Dental College and Hospital Hassan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anju Anu","family":"Jose","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Sri Hasanamba Dental College and Hospital Hassan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Medha","family":"Babshet","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Sri Hasanamba Dental College and Hospital Hassan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atul Anand","family":"Bajoria","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Sri Hasanamba Dental College and Hospital Hassan India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivas","family":"Naveen","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology Sri Hasanamba Dental College and Hospital Hassan India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,8,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2009.08.044"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(95)90678-9"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198909010-00019"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2008.02.028"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/52099930"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(93)90968-2"},{"key":"e_1_2_5_8_1","first-page":"877","article-title":"The phantom mandible","volume":"77","author":"Cadenat H","year":"1976","journal-title":"Rev Stomatol Chir Maxillofac"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(00)80027-X"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1054\/ijom.2002.0306"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.989"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.12.1340"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90227-7"},{"key":"e_1_2_5_14_1","first-page":"439","article-title":"Gorham\u2010Stout syndrome of the mandible","volume":"26","author":"Mathias K","year":"1986","journal-title":"Radiologe"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(83)90185-8"},{"key":"e_1_2_5_16_1","first-page":"538","article-title":"Massive osteolysis affecting the mandible","volume":"120","author":"Hampton J","year":"1966","journal-title":"Br Dent J"},{"key":"e_1_2_5_17_1","first-page":"255","article-title":"Massive lytic osteodystrophy or Gorham\u2010Stout disease of the craniomaxillofacial area","volume":"121","author":"Oujilal A","year":"2000","journal-title":"Rev Laryngol Otol Rhinol (Bord)"},{"key":"e_1_2_5_18_1","first-page":"433","article-title":"Massive osteolysis in the mandibular region caused by hemangiomatosis of the bone","volume":"45","author":"Knolle G","year":"1965","journal-title":"Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte"},{"key":"e_1_2_5_19_1","first-page":"787","article-title":"Massive osteolysis of the mandible: an attempt at reconstruction","volume":"32","author":"Booth DF","year":"1974","journal-title":"J Oral Surg"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00360944"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880110614"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-199507000-00013"},{"key":"e_1_2_5_23_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00428-003-0765-7","article-title":"Is angiomatosis an intrinsic pathohistological feature of massive osteolysis? 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