{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:53:59Z","timestamp":1740138839103,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T00:00:00Z","timestamp":1478217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to make an initial estimation on the effects of a sodium bicarbonate and xylitol spray (Cariex<jats:sup>\u00ae<\/jats:sup>), associated with non\u2010surgical periodontal therapy, in participants with primary Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Sj\u00f6gren's syndrome (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>) is a multisystem autoimmune disease that predominantly involves salivary and lachrymal glands, with the clinical effect of dry eyes and mouth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A prospective cohort of 22 women and two men has been evaluated. They were randomized into three groups (eight patients each): Group A) those treated once with non\u2010surgical periodontal therapy, education and motivation to oral hygiene, associated with the use of Cariex<jats:sup>\u00ae<\/jats:sup>; Group B) treated only with Cariex<jats:sup>\u00ae<\/jats:sup>; Group C) treated only with non\u2010surgical periodontal therapy, education and motivation to oral hygiene. Clinical variables described after treatment were unstimulated whole salivary flow, stimulated whole salivary flow, salivary <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>, reported pain (using Visual Analogue Scale) and the Periodontal Screening and Recording index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Salivary flow rate improved in all groups, but the difference was statistically significant only in those treated with Cariex<jats:sup>\u00ae<\/jats:sup>, alone or in combination with periodontal therapy. Gingival status improved in participants who underwent periodontal non\u2010surgical therapy while remained unchanged in those only treated with Cariex<jats:sup>\u00ae<\/jats:sup>. Reported pain decreased in all groups, showing the best result in participants treated with periodontal therapy together with Cariex<jats:sup>\u00ae<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We propose a practical approach for improving gingival conditions and alleviating oral symptoms in patients with <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>. Future randomized and controlled trials are however required to confirm these results as well as larger population, and also assessing other parameters due to oral dryness, possible oral infections and more comprehensive periodontal indices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12250","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T09:59:56Z","timestamp":1478253596000},"page":"208-214","source":"Crossref","is-referenced-by-count":3,"title":["Impact of a sodium carbonate spray combined with professional oral hygiene procedures in patients with Sj\u00f6gren's syndrome: an explorative study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-0799","authenticated-orcid":false,"given":"Alessio","family":"Gambino","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Broccoletti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Cafaro","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Cabras","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Carcieri","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo G.","family":"Arduino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences CIR \u2013 Dental School University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21591"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.02846.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1998.tb09643.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.09.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2004.01384.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0528.2006.00285.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(97)90144-X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328363eaa5"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-2085-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.61.6.554"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurger.2013.04.008"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2007.09.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90126-4"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.110619"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2001.70207.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2001.0056"},{"key":"e_1_2_7_18_1","first-page":"97","article-title":"Caries and periodontal conditions in patients with primary Sj\u00f6gren's syndrome","volume":"22","author":"Ravald N","year":"1998","journal-title":"Swed Dent J"},{"key":"e_1_2_7_19_1","first-page":"110","article-title":"Oral microbial flora in Sj\u00f6gren's syndrome","volume":"26","author":"Almst\u00e5hl A","year":"1999","journal-title":"J Rheumatol"},{"key":"e_1_2_7_20_1","first-page":"365","article-title":"Sj\u00f6gren's syndrome: oral manifestations and treatment, a dental perspective","volume":"89","author":"Cartee DL","year":"2015","journal-title":"J Dent Hyg"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2591.2012.02021.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9969(02)00214-5"},{"key":"e_1_2_7_23_1","first-page":"71","article-title":"Salivary ph after a glucosal rinse: effects of a new sodium bicarbonate mucoadhesive spray. 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