{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T06:48:37Z","timestamp":1765176517335},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Local Research and Development Board for Gothenburg and S\u00f6dra Bohusl\u00e4n."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate acceptance of treatment after oral sedation with midazolam in dental patients with major neurocognitive disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Midazolam is commonly used as premedication in paediatric dentistry, oral surgery and people suffering from dental fear. Little is known about its use in other patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dental and sedation records of 61 patients (64% women) sedated with midazolam were examined retrospectively. All records came from patients with major neurocognitive disorder who had been referred to a special dental care unit in Sweden due to uncooperative behaviour and sedated with orally administered midazolam between 2006 and 2011. Data concerning dose, degree of acceptance of dental treatment (four\u2010point scale) and number of possible interacting drugs were collected from dental records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On average, the participants were 80\u00a0years old (range: 62\u201093) and used 3.4 possible interacting drugs. The average midazolam dose was 0.11\u00a0mg\/kg body weight, which is in line with the regional medical guidelines for sedation. Twenty\u2010seven participants (44%) had no cooperation problems when sedated, twenty\u2010six (43%) were treated with minor adaptations, five had poor cooperation, and three were not possible to treat. No statistically significant differences were found for degree of acceptance of treatment and dose or number of possible interacting drugs. Antiepileptics were used by 13% (n=7) with <jats:italic>good<\/jats:italic> or <jats:italic>quite good<\/jats:italic> acceptance compared to 37% (n=3) among those with <jats:italic>poor<\/jats:italic> or <jats:italic>no<\/jats:italic> acceptance. Unfavourable side effects were rare; one participant became hyperactive and one drowsier than expected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sedation with orally administered midazolam seems to be effective and safe in dental treatment of uncooperative persons with major neurocognitive disorder.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12262","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T06:36:37Z","timestamp":1487313397000},"page":"299-305","source":"Crossref","is-referenced-by-count":9,"title":["Sedation with orally administered midazolam in elderly dental patients with major neurocognitive disorder"],"prefix":"10.1111","volume":"34","author":[{"given":"Lena","family":"Rignell","sequence":"first","affiliation":[{"name":"Clinic of Pedodontics and Special Dental Care Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Mikati","sequence":"additional","affiliation":[{"name":"Clinic of Pedodontics and Special Dental Care Sahlgrenska University Hospital  M\u00f6lndal Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Werts\u00e9n","sequence":"additional","affiliation":[{"name":"Clinic of Pedodontics and Special Dental Care Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Gerodontology Public Dental Service  Region V\u00e4stra G\u00f6taland Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"H\u00e4gglin","sequence":"additional","affiliation":[{"name":"Department of Gerodontology Public Dental Service  Region V\u00e4stra G\u00f6taland Sweden"},{"name":"Department of Behavioural &amp; Community Dentistry Institute of Odontology Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_3_1","first-page":"69","article-title":"Oral health of individuals aged 3\u201080\u00a0years in J\u00f6nk\u00f6ping, Sweden during 40\u00a0years (1973\u20102013). II. Review of clinical and radiographic findings","volume":"39","author":"Norderyd O","year":"2015","journal-title":"Swed Dent J"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-13-63"},{"key":"e_1_2_8_5_1","first-page":"95","article-title":"Who cares for the oral health of dependent elderly and disabled persons living at home? A qualitative study of case managers\u2019 knowledge, attitudes and initiatives","volume":"32","author":"Hagman\u2010Gustafsson ML","year":"2008","journal-title":"Swed Dent J"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-2358.2011.00507.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(00)80003-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.12585"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/09638288.2015.1074729"},{"key":"e_1_2_8_10_1","first-page":"67","article-title":"Interest of 50% nitrous oxide and oxygen premix sedation in gerodontology","volume":"4","author":"Nicolas E","year":"2009","journal-title":"Clin Interv Aging"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198503000-00017"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2010.501"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bdj.2008.521"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-015-0187-7"},{"key":"e_1_2_8_15_1","first-page":"105","article-title":"Rectal administration of midazolam for conscious sedation of uncooperative children in need of dental treatment","volume":"25","author":"Lindh\u2010Str\u00f6mberg U","year":"2001","journal-title":"Swed Dent J"},{"key":"e_1_2_8_16_1","first-page":"16","article-title":"The safety and efficacy of using a concentrated intranasal midazolam formulation for paediatric dental sedation","volume":"27","author":"Wood M","year":"2011","journal-title":"SAAD Dig"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071240"},{"key":"e_1_2_8_18_1","first-page":"97","article-title":"Conscious sedation by oral administration of midazolam in paediatric dental treatment","volume":"25","author":"Erlandsson AL","year":"2001","journal-title":"Swed Dent J"},{"key":"e_1_2_8_19_1","first-page":"175","article-title":"An evaluation of oral and nasal midazolam for pediatric dental sedation","volume":"61","author":"Hartgraves PM","year":"1994","journal-title":"ASDC J Dent Child"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03262557"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0901-5027(87)80155-8"},{"key":"e_1_2_8_22_1","first-page":"40","article-title":"Dosage of oral Midazolam in dentoalveolar surgery","volume":"93","author":"Rune J","year":"2001","journal-title":"Tandl\u00e4kartidningen"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2000.27.4.190"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-10-16"},{"key":"e_1_2_8_25_1","unstructured":"MagnussonMO.Pharmacodynamics of enzyme induction and its consequences for substrate elimination.2007. Thesis ISBN 978\u201091\u2010554\u20106860\u20106 Available at:http:\/\/urn.kb.se\/resolve?urn=urn:nbn:se:uu:diva-7812. Accessed May 8 2016."},{"key":"e_1_2_8_26_1","unstructured":"Electronic Medicines Compendium (eMC).Midazolam. Available at:http:\/\/www.medicines.org.uk\/emc\/medicine\/25538. Accessed May 12 2016."},{"key":"e_1_2_8_27_1","unstructured":"American Society of Anesthesiologists.ASA physical status classification system. Available at:https:\/\/www.asahq.org\/resources\/clinical-information\/asa-physical-status-classification-system. Accessed February 18 2016."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1980.0376"},{"key":"e_1_2_8_29_1","unstructured":"WHO Collaborating Centre for Drugs Statistics Methodology.Guidelines for ATC classification and DDD assignment.2015. Oslo 2014. Available at:http:\/\/www.whocc.no\/filearchive\/publications\/2016_guidelines_web.pdf. Accessed May 6th 2016."},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2007.10.015"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008315"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.6.746"}],"container-title":["Gerodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fger.12262","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ger.12262","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T14:59:23Z","timestamp":1694271563000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ger.12262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1111\/ger.12262"],"URL":"https:\/\/doi.org\/10.1111\/ger.12262","archive":["Portico"],"relation":{},"ISSN":["0734-0664","1741-2358"],"issn-type":[{"value":"0734-0664","type":"print"},{"value":"1741-2358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]}}}