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Premenopausal 2. Perimenopausal and 3. Postmenopausal. <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> and gingival tissue samples were collected from sites with maximum probing depth. Tissue <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> was extracted from the gingival sample and 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG in the extracted <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> samples were measured using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a highly significant difference in the overall <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels among the three groups with the pairwise difference being highly significant between the premenopausal\u2010postmenopausal groups and perimenopausal\u2010postmenopausal groups. However, no overall significant differences in tissue 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels were found among the three groups. Pairwise, highly significant differences were found between the premenopausal\u2010postmenopausal groups and perimenopausal\u2010postmenopausal groups for tissue 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels. No significant correlations were found between various measure of periodontal disease and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content>\/tissue 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels among all the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Premenopausal\u2010postmenopausal and perimenopausal\u2010postmenopausal transition resulted in significant increase in tissue and <jats:styled-content style=\"fixed-case\">GCF<\/jats:styled-content> 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG levels. However, no association was found between stages of reproductive ageing and tissue levels of 8\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>dG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12279","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T06:06:53Z","timestamp":1496297213000},"page":"382-389","source":"Crossref","is-referenced-by-count":6,"title":["Estimation of tissue and crevicular fluid oxidative stress marker in premenopausal, perimenopausal and postmenopausal women with chronic periodontitis"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8912-8953","authenticated-orcid":false,"given":"Rampalli Viswa","family":"Chandra","sequence":"first","affiliation":[{"name":"Department of Periodontics SVS Institute of Dental Sciences  Mahabubnagar Telangana 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