{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T21:59:50Z","timestamp":1783807190138,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H06809, 17K11694"],"award-info":[{"award-number":["15H06809, 17K11694"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to investigate the alterations in the salivary IgA levels of elderly persons administered yogurt fermented with<jats:italic>Lactobacillus delbrueckii<\/jats:italic>ssp.<jats:italic>bulgaricus<\/jats:italic>(<jats:italic>L.\u00a0bulgaricus<\/jats:italic>) OLL1073R\u20101, which has been reported to reduce the risk of colds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Salivary immunoglobulin (Ig)A plays an important role in the defence of the oral cavity mucous membrane against foreign antigens and pathogens. Accordingly, low levels of salivary IgA are associated with an increased risk of upper respiratory tract infection. Furthermore, salivary IgA secretion has been reported to decrease with age. Recently, several studies have reported that certain strains of<jats:italic>Lactobacillus<\/jats:italic>and their products can modulate the immune response, but there are currently few studies on the effects of on the IgA level in human saliva.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>This was a before\u2010after non\u2010randomised intervention study. Thirty\u2010seven elderly persons (mean age, 82.7\u00a0years) residing in a single nursing home ingested 112\u00a0g of the yogurt every morning for 12\u00a0weeks. The participants\u2019 saliva was collected before and after 4, 8 and 12\u00a0weeks of yogurt intake.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that yogurt intake affected the concentration of IgA in the saliva (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001). Additionally, yogurt intake and the body weight of the participants affected the IgA flow rate of saliva (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0003 and .03, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Continuous intake of yogurt fermented with<jats:italic>L.\u00a0bulgaricus<\/jats:italic>OLL1073R\u20101 may help improve the mucosal immune function in elderly people with weakened immune systems.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12296","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T02:52:48Z","timestamp":1503543168000},"page":"479-485","source":"Crossref","is-referenced-by-count":21,"title":["Effects of yogurt fermented with<i>Lactobacillus delbrueckii<\/i>ssp.\u00a0<i>bulgaricus<\/i>OLL1073R\u20101 on the IgA flow rate of saliva in elderly persons residing in a nursing home: A before\u2010after non\u2010randomised intervention study"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1724-0425","authenticated-orcid":false,"given":"Yuko","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Junior College School of Dental Hygiene Kanagawa Dental University Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Oral Science Division of Environmental Pathology Graduate School of Dentistry Kanagawa Dental UniversityGraduate School of Dentistry Yokosuka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juri","family":"Saruta","sequence":"additional","affiliation":[{"name":"Department of Oral Science Division of Environmental Pathology Graduate School of Dentistry Kanagawa Dental UniversityGraduate School of Dentistry Yokosuka 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