{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:19:35Z","timestamp":1771006775936,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T00:00:00Z","timestamp":1542672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["15K11436"],"award-info":[{"award-number":["15K11436"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["24593177"],"award-info":[{"award-number":["24593177"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of this study was to clarify by histopathological examination the origin of oral membranous substances deposited on the palate, tongue, buccal mucosa and teeth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Several investigators have reported membranous substances deposited in the mouths of bedridden elderly persons requiring nursing care without oral intake. However, the precise nature and origin of the substances are poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010nine specimens were taken from the oral cavity of bedridden patients, that is, the palate, dorsum of the tongue, the cheek and teeth. Sections were stained with haematoxylin and eosin stain, alcian\u2010blue and periodic acid\u2010Schiff stain (AB\u2010PAS) and antibodies for pankeratin (AE1AE3) and leukocyte common antigen (LCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All specimens showed a film\u2010like nature coloured from tan to white, accompanied by a mucous substance. Histologically, specimens of all sites had a similar feature of the combination of basophilic amorphous and eosinophilic lamellar features. The basophilic substance was positive for AB\u2010PAS, and PAS\u2010positive glycogen granules were also noted in the lamellar structure. Immunochemistry revealed various degrees of pankeratin positive substance and LCA\u2010positive inflammatory cell infiltration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The oral membranous substance was composed of keratin and mucin with inflammation. These results suggest that the deposition of the oral membranous substance is a pathological condition or oral mucositis caused by dry mouth.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12379","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T08:01:15Z","timestamp":1542787275000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histopathological evaluation of oral membranous substance in bedridden elderly persons without oral intake in Japan"],"prefix":"10.1111","volume":"36","author":[{"given":"Fa\u2010Chih","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Dentistry Cathay General Hospital Sijhih Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-5873","authenticated-orcid":false,"given":"Tadashi","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Shinotsuka","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohta","family":"Miyahara","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Isono","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyasu","family":"Mochiduki","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouhei","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Special Care Dentistry Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumitsu","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanaga","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Kakinoki","sequence":"additional","affiliation":[{"name":"Department of Special Needs and Geriatric Dentistry Kyushu Dental University Kitakyushu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8222-9658","authenticated-orcid":false,"given":"Hiromasa","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Hard Tissue Pathology Unit, Graduate School of Oral Medicine Matsumoto Dental University Shiojiri Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3143\/geriatrics.52.170"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-017-0524-2"},{"key":"e_1_2_7_4_1","first-page":"88","article-title":"Improving findings in the mouth of elderly persons with open mouth at all times by oral moisturizers","volume":"36","author":"Yoshida R","year":"2006","journal-title":"Jpn Nurs Assocn: Ronen Kaigo"},{"issue":"7","key":"e_1_2_7_5_1","first-page":"647","article-title":"Intraoral trouble shooting","volume":"8","author":"Nishikubo S","year":"2010","journal-title":"Kokyuki Care"},{"key":"e_1_2_7_6_1","first-page":"93","article-title":"Investigation on improving intraoral environments. 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