{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:17:49Z","timestamp":1787066269240,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JSPS KAKENHI 15K11258"],"award-info":[{"award-number":["JSPS KAKENHI 15K11258"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JSPS KAKENHI 18H02994"],"award-info":[{"award-number":["JSPS KAKENHI 18H02994"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this comprehensive systematic review and meta\u2010analysis was to investigate the pathology and pathogenesis of medication\u2010related osteonecrosis of the jaw (MRONJ) in rodents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Medication\u2010related osteonecrosis of the jaw occurs in patients taking antiresorptive drugs, such as bisphosphonates and denosumab, and anti\u2010angiogenesis agents. However, there is limited information about the pathology of MRONJ at the clinical level. Moreover, no information about the exact mechanisms of MRONJ is clinically available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The PubMed, SCOPUS and Medline databases were used to search for relevant articles up to April 2018 by two independent reviewers. A systematic review and meta\u2010analysis were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 1841 studies, 10 articles met the eligibility criteria. The most commonly observed pathology of MRONJ\u2010like lesions was exposed bone without epithelial coverage, decreases in the number of osteocytes and increases in necrotic bone with more empty lacunae. No definitive pathogenesis of MRONJ\u2010like lesions was found. Both zoledronic acid (ZA) monotherapy and ZA\/chemotherapeutic and\/or dexamethasone combination therapy were significant high\u2010risk factors for developing MRONJ\u2010like lesions (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.00001 and\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.0001, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Based on rodent studies, common pathological findings were extracted in bisphosphonate\u2010related ONJ (BRONJ)\u2010like lesions, whereas no definitive pathogenesis was identified. There is no information about the pathology and pathogenesis of denosumab\u2010related ONJ. These findings clearly suggest that accumulation of scientific evidence based on animal studies is absolutely necessary to explore the pathology and pathogenesis of MRONJ in humans. ZA administration would be a significant risk factor for developing BRONJ\u2010like lesions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ger.12416","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T08:59:25Z","timestamp":1564736365000},"page":"313-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Medication\u2010related osteonecrosis of the jaw\u2010like lesions in rodents: A comprehensive systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9891-9987","authenticated-orcid":false,"given":"Shinichiro","family":"Kuroshima","sequence":"first","affiliation":[{"name":"Department Applied Prosthodontics, Institute of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneteru","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department Applied Prosthodontics, Institute of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry, Institute of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sawase","sequence":"additional","affiliation":[{"name":"Department Applied Prosthodontics, Institute of Biomedical Sciences Nagasaki University Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-0843"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.11.020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(03)00720-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2009.10.010"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.5424"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607948"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2015.01.026"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.00872.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.09.016"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-017-0872-1"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090592"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2016.01.009"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.05.013"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.652305"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.06.011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.735795"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.22210"},{"issue":"5","key":"e_1_2_7_20_1","first-page":"5161","article-title":"A novel model of bisphosphonate\u2010related osteonecrosis of the jaw in rats","volume":"8","author":"Yang H","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2015.08.008"},{"issue":"4","key":"e_1_2_7_22_1","first-page":"219","article-title":"Meta\u2010analysis: pitfalls and hints","volume":"5","author":"Greco T","year":"2013","journal-title":"Heart Lung Vessel"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2490"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2097"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.07.010"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0128021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513487558"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.130094"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2405"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2009.07.011"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2006.00391.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0866-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1439"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3292"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0802633"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215952"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3073"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.8879"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-0042"}],"container-title":["Gerodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ger.12416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ger.12416","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ger.12416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T17:12:58Z","timestamp":1694193178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ger.12416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,2]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/ger.12416"],"URL":"https:\/\/doi.org\/10.1111\/ger.12416","archive":["Portico"],"relation":{},"ISSN":["0734-0664","1741-2358"],"issn-type":[{"value":"0734-0664","type":"print"},{"value":"1741-2358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,2]]},"assertion":[{"value":"2018-04-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}