{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T04:29:21Z","timestamp":1788150561992,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T00:00:00Z","timestamp":1626739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K09754"],"award-info":[{"award-number":["18K09754"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>This study examined whether time\u2010activity curves (TAC) can be used to differentiate between patients with and without Sj\u00f6gren's syndrome using SPECT\/CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen xerostomia patients (5 with Sj\u00f6gren's syndrome and 8 without Sj\u00f6gren's syndrome) underwent SPECT\/CT. Salivary gland secretion data were digitally observed, producing separate time\u2010activity curves (TAC) for the submandibular glands and parotid glands using SPECT\/CT. The salivary gland secretion fraction was defined as A (before stimulation test [counts\/frame]) divided by B (after stimulation test [counts\/frame]). The A\/B ratios of patients with Sj\u00f6gren's syndrome and those without Sj\u00f6gren's syndrome were compared using the Mann\u2010Whitney U test for nonparametric data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The A\/B ratio of parotid glands with Sj\u00f6gren's syndrome (1.3\u00a0\u00b1\u00a00.2) was significantly lower than for those without Sj\u00f6gren's syndrome (2.7\u00a0\u00b1\u00a00.7). The A\/B ratio of submandibular glands with Sj\u00f6gren's syndrome (1.3\u00a0\u00b1\u00a00.4) is significantly lower than for those without Sj\u00f6gren's syndrome (1.8\u00a0\u00b1\u00a00.6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The TAC for the submandibular glands and parotid glands using SPECT\/CT may be useful for the objective and quantitative diagnosis of Sj\u00f6gren's syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12584","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T05:50:44Z","timestamp":1626846644000},"page":"297-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["A clinical pilot study of salivary gland secretion for xerostomia patients with Sj\u00f6gren\u2019s syndrome using SPECT\/CT"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0832-4619","authenticated-orcid":false,"given":"Yoshiyuki","family":"Minami","sequence":"first","affiliation":[{"name":"Quantitative Diagnostic Imaging Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics Course of Applied Science The Nippon Dental University Graduate School of Life Dentistry at Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9169-8429","authenticated-orcid":false,"given":"Ichiro","family":"Ogura","sequence":"additional","affiliation":[{"name":"Quantitative Diagnostic Imaging Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics Course of Applied Science The Nippon Dental University Graduate School of Life Dentistry at Niigata  Niigata Japan"},{"name":"Department of Oral and Maxillofacial Radiology The Nippon Dental University School of Life Dentistry at Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,20]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"63","article-title":"Magnetic resonance sialography and salivary gland scintigraphy of parotid glands in Sj\u00f6gren\u2019s syndrome","volume":"21","author":"Ogura I","year":"2018","journal-title":"Chin J Dent 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