{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:20:11Z","timestamp":1788906011423,"version":"build-2803163510"},"reference-count":72,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T00:00:00Z","timestamp":1635811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oral bisphosphonates are widely used in the treatment of bone resorptive diseases. There is an evidence that oral bisphosphonates can exert adverse effects on the oral mucosa independently of their effects on the jaw bones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To systematically map the literature on adverse effects of oral bisphosphonates on the oral mucosa of adults with bone resorptive diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Scoping review of the literature, including different study designs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Systematic searches of the PubMed, LILACS, Google Scholar and EMBASE databases were conducted. Two independent reviewers screened titles and abstracts according to predetermined criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search retrieved 26 unique articles, comprising 22 case reports, one case series and three reviews describing a total of 56 cases of oral adverse events related to oral bisphosphonates. 88% of the reported cases were female suffering from comorbidities other than metabolic bone diseases. The improper use of the oral bisphosphonate was the most suspected cause of the adverse effect on the oral mucosa. Its management mainly involved withdrawal of the medication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adverse effects on the oral mucosa can develop from using oral bisphosphonates. Standardised registration of these adverse effects in university clinics and private practises could provide additional information about their occurrence and severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12590","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T08:16:15Z","timestamp":1635840975000},"page":"330-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Oral bisphosphonates: Adverse effects on the oral mucosa not related to the jaw bones. A scoping review"],"prefix":"10.1111","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9919-5359","authenticated-orcid":false,"given":"Christina","family":"Psimma","sequence":"first","affiliation":[{"name":"BT\u2010Academy Center for Special Care in Dentistry Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoi","family":"Psimma","sequence":"additional","affiliation":[{"name":"Private Practice  Zoetermeer The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna C.","family":"Willems","sequence":"additional","affiliation":[{"name":"Department Internal Medicine, Section Geriatrics Amsterdam UMC  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J.","family":"Kl\u00fcter","sequence":"additional","affiliation":[{"name":"BENECOMO Flemish\u2010Netherlands Geriatric Oral Research Group  Nijmegen The Netherlands"},{"name":"College of Dental Sciences Radboud University Medical Centre  Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claar D.","family":"van der Maarel\u2010Wierink","sequence":"additional","affiliation":[{"name":"BT\u2010Academy Center for Special Care in Dentistry Amsterdam  Amsterdam The Netherlands"},{"name":"BENECOMO Flemish\u2010Netherlands Geriatric Oral Research Group  Nijmegen The Netherlands"},{"name":"College of Dental Sciences Radboud University Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Oral Medicine Academic Centre for Dentistry Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-88-470-2083-2","volume-title":"Bisphosphonates and osteonecrosis of the jaw: a multidisciplinary approach","author":"De Ponte FS","year":"2012"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2014.09.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/s8756\u20103282(03)00112\u20101"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102018\u2010027049"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.04.054"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.07.010"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2008.10.005"},{"issue":"5","key":"e_1_2_8_9_1","first-page":"E396","article-title":"Bisphosphonates and oral pathology I. General and preventive aspects","volume":"11","author":"Ponte Fern\u00e1ndez N","year":"2006","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0391\u20101977.19.03052\u20109"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S37199"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.1226"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.01.003"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199610033351403"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2007.01.014"},{"issue":"3","key":"e_1_2_8_16_1","first-page":"187","article-title":"A drinkable formulation of alendronate: Potential to increase compliance and decrease upper gi irritation","volume":"10","author":"Brandi ML","year":"2013","journal-title":"Clin Cases Miner Bone Metab"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010014\u20102647\u2010z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2016.06.001"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2014.04.031"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2004.02.004"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.21726\/rsbo.v10i4.942"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784\u2010010\u20100507\u20106"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12154"},{"issue":"3","key":"e_1_2_8_24_1","first-page":"1","article-title":"Effect of alendronic acid on buccal mucosa","volume":"4","author":"Papamitsou T","year":"2018","journal-title":"J. Dent. Oral Health"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56020051"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.13078"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2011.03.046"},{"key":"e_1_2_8_28_1","unstructured":"Landelijke registratie evaluatie bijwerkingen (LAREB). Bisphosphonates and stomatitis.https:\/\/databankws.lareb.nl\/Downloads\/kwb_2009_2_bisph.pdf"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18\u20100850"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000050"},{"issue":"9","key":"e_1_2_8_31_1","first-page":"612","article-title":"Oral ulcerations induced by monosodium alendronate. \"Ulc\u00e9rations buccales \u00e0 l'alendronate monosodique\"","volume":"22","author":"Chevallier JM","year":"2003","journal-title":"Nouvelles Dermatologiques"},{"key":"e_1_2_8_32_1","first-page":"182","article-title":"Ulceration muqueuses topographique atypiques avec l'alendronate","volume":"53","author":"Spreux A","year":"1998","journal-title":"Therapie"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s100670050116"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600\u20100714.2000.291006.x"},{"key":"e_1_2_8_35_1","first-page":"1138","article-title":"Alendronate monosodique (Fosamax\u00ae). (Esophagites et ulcerations orales)","volume":"127","author":"Schmutz J","year":"2000","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.07.030"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0151\u20109638(05)79521\u20101"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmicm054413"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(07)89200-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1157\/13125415140"},{"key":"e_1_2_8_41_1","first-page":"35","article-title":"Oral Ulcers Caused by Alendronate use","volume":"23","author":"Cinemre H","year":"2008","journal-title":"Rheumatism"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjoms.2008.08.005"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1578\u20102190(09)70016\u20102"},{"key":"e_1_2_8_44_1","first-page":"a156","article-title":"Oral erosive mucositis associated with improper administration of a drug","volume":"76","author":"Ng S","year":"2010","journal-title":"J can Dent Assoc"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2010.04.035"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.5177\/ntvt.2010.08.09189"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.6014\/jjomm.16.24"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoms.2011.06.001"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2012.01.025"},{"issue":"2","key":"e_1_2_8_50_1","first-page":"18","article-title":"An Alendronate\u2010Induced Oral Lichenoid Reaction","volume":"4","author":"Vu\u010di\u0107evi\u0107\u2010Boras V","year":"2014","journal-title":"J Dent Med Sci"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1159\/000439347"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.5272\/jimab.2017231.1487"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.53653"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2018.06.003"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/ger.12378"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.12968\/denu.2018.45.1.38"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.5794\/jjoms.65.599"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aprim.2019.12.008"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.5794\/jjoms.66.25"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/ors.12540"},{"key":"e_1_2_8_61_1","first-page":"301","volume-title":"Users\u2019 guide to the medical literature. A manual for evidence\u2010based clinical practice","author":"Levine M","year":"2015"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2005.00434.x"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S23404"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555\u20100859"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572\u20100241.1998.01395.x"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmacy5020030"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15020310"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2013.10.009"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223\u2010018\u201000512\u2010x"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1474-9"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016\u20101801"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000014340"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.09.008"}],"container-title":["Gerodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ger.12590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ger.12590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ger.12590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T22:19:59Z","timestamp":1692656399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ger.12590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,2]]},"references-count":72,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1111\/ger.12590"],"URL":"https:\/\/doi.org\/10.1111\/ger.12590","archive":["Portico"],"relation":{},"ISSN":["0734-0664","1741-2358"],"issn-type":[{"value":"0734-0664","type":"print"},{"value":"1741-2358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,2]]},"assertion":[{"value":"2021-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}