{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T17:53:47Z","timestamp":1786902827332,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>There is a relative lack of evidence from observational studies of older populations investigating the association between chronic periodontitis and cerebro\u2010cardiovascular diseases. Accordingly, we investigated the risk of cerebro\u2010cardiovascular diseases according to the severity of chronic periodontitis among older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on older adults with chronic periodontitis were extracted from the Korea National Health Insurance Service\u2010Senior Cohort Database using diagnosis codes and dental procedures. Participants were divided into two exposure groups. Among 46\u2009737 participants eligible for inclusion, 21\u2009905 (46.9%) had newly diagnosed mild chronic periodontitis, and 24\u2009832 (53.1%) had newly diagnosed severe chronic periodontitis. To determine the risk of cerebro\u2010cardiovascular diseases, including ischemic stroke, haemorrhagic stroke, and myocardial infarction, multivariable\u2010adjusted Cox proportional hazards modelling was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) in this retrospective follow\u2010up study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 3453 (7.4%) outcomes were identified during a mean follow\u2010up of 6.1\u2009years. Kaplan\u2013Meier analysis revealed that disease\u2010free probability was lower in the severe group than in the mild group (log\u2010rank <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). In the multivariable\u2010adjusted model, the HR for cerebro\u2010cardiovascular diseases in the severe group (relative to the mild group) was 1.16 (95% CI: 1.09\u20131.25). In individual outcome analysis, ischemic stroke and myocardial infarction were associated with chronic periodontitis severity, but haemorrhagic stroke was not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The severity of chronic periodontitis could be associated with the risk of cerebro\u2010cardiovascular diseases in older adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ger.12722","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T18:10:21Z","timestamp":1697566221000},"page":"400-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Chronic periodontitis and risk of cerebro\u2010cardiovascular diseases among older Koreans"],"prefix":"10.1111","volume":"41","author":[{"given":"Kyeung\u2010Ae","family":"Jang","sequence":"first","affiliation":[{"name":"Department of Dental Hygiene Silla University  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Rin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dental Hygiene Silla University  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangmin","family":"Joo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dong\u2010A University Hospital  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0047-3102","authenticated-orcid":false,"given":"Minkook","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Physiology Dong\u2010A University College of Medicine  Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4235\/agmr.19.0013"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.5124\/jkma.2002.45.1.41"},{"key":"e_1_2_11_4_1","unstructured":"Health insurance review and assessment service.2023. 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