{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:10:35Z","timestamp":1773015035162,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["420698\/2018\u20133"],"award-info":[{"award-number":["420698\/2018\u20133"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Gerodontology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This article reports a case of medication\u2010related osteonecrosis of the jaw (MRONJ) associated with multiple myeloma (MM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bisphosphonates (BPs) are constantly used as part of the treatment for MM. The main adverse effects of bisphosphonates are renal insufficiency and medication\u2010related osteonecrosis of the jaw (MRONJ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A 67\u2010year\u2010old female with a previous diagnosis of MM and undergoing current receiving intravenous injections of pamidronate underwent a tooth extraction and subsequently developed MRONJ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MRONJ was managed with clindamycin, surgical removal of bony sequestrum and curettage. At 3\u2009years of follow\u2010up, the patient was asymptomatic with no clinical changes and panoramic radiography without evidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Management of patients under antiresorptive drugs who require invasive dental procedures is challenging. Therefore, interprofessional collaboration, especially between the general practitioner and oncologist and\/or haematologist, is essential to reach the best clinical approach and reduce the risk of MRONJ.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ger.12758","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T13:06:16Z","timestamp":1741698376000},"page":"119-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Medication\u2010related osteonecrosis of the jaw in an older patient with multiple myeloma"],"prefix":"10.1111","volume":"42","author":[{"given":"Larissa Couto","family":"de Freitas","sequence":"first","affiliation":[{"name":"School of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Silvestre","family":"de Aquino Silva","sequence":"additional","affiliation":[{"name":"School of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-2441","authenticated-orcid":false,"given":"Marta","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"School of Dentistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-090X","authenticated-orcid":false,"given":"Carine Ervolino","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Departament of Pathology and Parasitology Biomedical Science Institute, Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3134-7659","authenticated-orcid":false,"given":"Felipe 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