{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:28:07Z","timestamp":1790220487759,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the effect of pimobendan, a positive inotropic agent, in elderly patients with frequent readmission as a result of heart failure despite conventional therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pimobendan was given to five male patients with severe chronic heart failure (<jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ew <jats:styled-content style=\"fixed-case\">Y<\/jats:styled-content>ork <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>eart <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssociation class <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\u2013<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) (age range 69\u201389 years; mean 78\u2009\u00b1\u20098 years; ischemic cardiomyopathy in three cases, dilated cardiomyopathy in two cases) who required repeated admission for heart failure despite conventional therapy with angiotensin inhibitors, beta\u2010blockers, diuretics and anti\u2010arrhythmic agents. After the addition of pimobendan at a dose of 1.25\u20133.75\u2009mg\/day, we evaluated serum levels of brain natriuretic peptide (<jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content>), left ventricular ejection fraction (<jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content>), septal e\u2032 and left ventricular end\u2010diastolic diameter (<jats:styled-content style=\"fixed-case\">LVDD<\/jats:styled-content>) by echocardiography, as well as readmission rates for more than 2 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The serum level of <jats:styled-content style=\"fixed-case\">BNP<\/jats:styled-content> significantly decreased after treatment with pimobendan, although its level returned to pretreatment levels after 2 years. <jats:styled-content style=\"fixed-case\">LVEF<\/jats:styled-content> significantly improved after the treatment, with the improvement continuing beyond the 2 years, although <jats:styled-content style=\"fixed-case\">LVDD<\/jats:styled-content> did not change after treatment. Septal e\u2032 significantly improved after the treatment, although its level returned to pretreatment levels at 2 years after the treatment. Readmission rates significantly decreased for 2 years after the treatment, although one patient required cardiac resynchronization therapy for severe heart failure, and another patient required cardiac pacemaker implantation for sick sinus syndrome 2 years after adding pimobendan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pimobendan in conjunction with conventional therapy for heart failure decreases the readmission rate in elderly patients with severe heart failure for at least 2 years. <jats:bold>Geriatr Gerontol Int 2014; 14: 109\u2013114.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12067","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T06:42:55Z","timestamp":1366008175000},"page":"109-114","source":"Crossref","is-referenced-by-count":7,"title":["Effect of pimobendan in addition to standard therapy for heart failure on prevention of readmission in elderly patients with severe chronic heart failure"],"prefix":"10.1111","volume":"14","author":[{"given":"Hiroaki","family":"Kawano","sequence":"first","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"},{"name":"Department of Cardiovascular Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuji","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"},{"name":"Department of Cardiovascular Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osami","family":"Satoh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"},{"name":"Department of Cardiology Japanese Red Cross Nagasaki Genbaku Hospital  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"},{"name":"Department of Cardiology Sasebo Municipal General Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Hayano","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"},{"name":"Department of Cardiology Sasebo Municipal General Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakatomi","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yamasa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Nagasaki Rosai Hospital  Sasebo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Maemura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Nagasaki University Graduate School of Biomedical Sciences  Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe020115"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000039105.49749.6F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-9842(01)00123-4"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020265"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200102000-00008"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(87)90225-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.76.3.223"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.66.149"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.08.016"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052256"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-200006000-00011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(00)00803-1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1020608724335"}],"container-title":["Geriatrics &amp; 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