{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:59:19Z","timestamp":1792652359463,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2014,1]]},"abstract":"Aim<\/jats:title>Single photon emission computed tomography (SPECT<\/jats:styled-content>) studies showed that regional cerebral blood flow (rCBF<\/jats:styled-content>) abnormalities in idiopathic rapid eye movement (REM<\/jats:styled-content>) sleep behavior disorder (iRBD<\/jats:styled-content>) are similar to those seen in P<\/jats:styled-content>arkinson's disease (PD<\/jats:styled-content>) and dementia with L<\/jats:styled-content>ewy bodies (DLB<\/jats:styled-content>). The aim of the present study was to assess the longitudinal rCBF<\/jats:styled-content> changes in patients with iRBD<\/jats:styled-content> using repeated SPECT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nine patients with iRBD<\/jats:styled-content> (7 men and 2 women; mean age 71.1\u2009\u00b1\u20093.2 years) underwent baseline and follow\u2010up SPECT<\/jats:styled-content> studies (a mean interval of 22.8\u2009\u00b1\u20099.2 months).<\/jats:p><\/jats:sec>Results<\/jats:title>A decrease in rCBF<\/jats:styled-content> was found in bilateral parietotemporal and occipital areas at the first and second SPECT<\/jats:styled-content>. Compared with the first SPECT<\/jats:styled-content>, the second SPECT<\/jats:styled-content> showed a decreased rCBF<\/jats:styled-content> in the medial portions of the parietooccipital lobe with a significant decrease in rCBF<\/jats:styled-content> of the right posterior cingulate. None of the patients showed any neurological deficits, including extrapyramidal and cerebellar signs, visual hallucinations, and neuropsychological impairments during the study.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>These findings suggest that longitudinal measurements of rCBF<\/jats:styled-content> can show the presence of progressing neurodegenerative process in iRBD<\/jats:styled-content>. Longitudinal SPECT<\/jats:styled-content> study can be used to monitor the progression of degenerative process in patients with iRBD<\/jats:styled-content>, even though there were no evolving neurological and neuropsychiatric impairments. 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