{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:06:14Z","timestamp":1787630774717,"version":"build-2736575974"},"reference-count":86,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T00:00:00Z","timestamp":1377734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007279","name":"Shanghai Municipal Health Bureau","doi-asserted-by":"crossref","award":["2011-144"],"award-info":[{"award-number":["2011-144"]}],"id":[{"id":"10.13039\/501100007279","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The development of presbycusis, or age\u2010related hearing loss, is determined by a combination of genetic and environmental factors. The auditory periphery exhibits a progressive bilateral, symmetrical reduction of auditory sensitivity to sound from high to low frequencies. The central auditory nervous system shows symptoms of decline in age\u2010related cognitive abilities, including difficulties in speech discrimination and reduced central auditory processing, ultimately resulting in auditory perceptual abnormalities. The pathophysiological mechanisms of presbycusis include excitotoxicity, oxidative stress, inflammation, aging and oxidative stress\u2010induced <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage that results in apoptosis in the auditory pathway. However, the originating signals that trigger these mechanisms remain unclear. For instance, it is still unknown whether insulin is involved in auditory aging. Auditory aging has preclinical lesions, which manifest as asymptomatic loss of periphery auditory nerves and changes in the plasticity of the central auditory nervous system. Currently, the diagnosis of preclinical, reversible lesions depends on the detection of auditory impairment by functional imaging, and the identification of physiological and molecular biological markers. However, despite recent improvements in the application of these markers, they remain under\u2010utilized in clinical practice. The application of antisenescent approaches to the prevention of auditory aging has produced inconsistent results. Future research will focus on the identification of markers for the diagnosis of preclinical auditory aging and the development of effective interventions. <jats:bold>Geriatr Gerontol Int 2014; 14: 40\u201353.<\/jats:bold><\/jats:p>","DOI":"10.1111\/ggi.12124","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T06:38:51Z","timestamp":1377758331000},"page":"40-53","source":"Crossref","is-referenced-by-count":20,"title":["Current status of auditory aging and anti\u2010aging research"],"prefix":"10.1111","volume":"14","author":[{"given":"Qingwei","family":"Ruan","sequence":"first","affiliation":[{"name":"Central Lab Shanghai Institute of Geriatrics and Gerontology Huadong Hospital, Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Central Lab Shanghai Institute of Geriatrics and Gerontology Huadong Hospital, Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Central Lab Shanghai Institute of Geriatrics and Gerontology Huadong Hospital, Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuowei","family":"Yu","sequence":"additional","affiliation":[{"name":"Central Lab Shanghai Institute of Geriatrics and Gerontology Huadong Hospital, Shanghai Medical College, Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2102"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.02.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00131-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00191-3"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/156.3.449"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-008-0123-1"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.10.008"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2003.10.031"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2006.tb02210.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2011.02.005"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm292"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20375"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00047.2009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl940"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2008.12.005"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/63.1.73"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn402"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.04.001"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010043"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.037788"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3000271"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000183694.10583.12"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.049205"},{"key":"e_1_2_9_26_1","first-page":"449","article-title":"Mitochondrial DNA deletions associated with ageing and possibly presbycusis: a human archival temporal bone study","volume":"4","author":"Bai U","year":"1997","journal-title":"Am J Otol"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1112125"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.01.014"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1779509"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05772"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.12.027"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-009-9230-5"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338588"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.10.014"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M611782200"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.06.003"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.09.081"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7597"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.01.009"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AUD.0000079802.82344.B5"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21602"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2010.04.006"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0908786106"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00138-5"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-30"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.079"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010075"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.03.022"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/63.1.195"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.07.014"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4678-11.2012"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21402"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(02)00155-9"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01121.2003"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.01.014"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.3766\/jaaa.23.8.5"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.06.009"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2011.05.004"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1044\/1092-4388(2004\/021)"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2009.234"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2012.08.016"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21771"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812446904"},{"key":"e_1_2_9_64_1","first-page":"167","article-title":"Investigation of the effect of moderate calories restriction on aging at molecular level","volume":"16","author":"Tong TJ","year":"2010","journal-title":"Geriatr Health"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.10.002"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.01.006"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08221"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.06.010"},{"key":"e_1_2_9_69_1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1523\/JNEUROSCI.21-02-00570.2001","article-title":"Intracellular signals that control cell proliferation in mammalian balance epithelia: key roles for phosphatidylinositol\u20103 kinase, mammalian target of rapamycin, and S6 kinases in preference to calcium, protein kinase C, and mitogen\u2010activated protein kinase","volume":"21","author":"Montcouquiol M","year":"2001","journal-title":"J Neurosci"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNR.0b013e328308b338"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200005000-00003"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.06.009"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.09.125"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.10.032"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.04.049"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2008.05.023"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.216.53"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.08.006"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws146"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711797535254"},{"key":"e_1_2_9_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2005.05.009"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.07.016"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05875"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08882"},{"key":"e_1_2_9_85_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age","volume":"47","author":"Rossi DJ","year":"2007","journal-title":"Nature"},{"key":"e_1_2_9_86_1","unstructured":"YuZW LiJ ChenYM MaYX BaoZJ ZhuY.The development and investigation of anti\u2010aging medicine and health preservation. 2011 National anti\u2010aging and geriatric diseases prevention.2011; Summit: 2\u20136."},{"issue":"1","key":"e_1_2_9_87_1","first-page":"6","article-title":"Progress on non\u2010human primate rhesus aging and anti\u2010aging research","volume":"44","author":"Ruan QW","year":"2013","journal-title":"Prog Physiol Sci"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fggi.12124","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.12124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T22:33:43Z","timestamp":1696286023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.12124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,29]]},"references-count":86,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/ggi.12124"],"URL":"https:\/\/doi.org\/10.1111\/ggi.12124","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,29]]}}}