{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T11:40:07Z","timestamp":1746358807646,"version":"3.40.4"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,27]],"date-time":"2014-08-27T00:00:00Z","timestamp":1409097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Many intracellular components have been implicated in the regulation of redox homeostasis, but homeostasis can be unbalanced by reactive species (<jats:styled-content style=\"fixed-case\">RS<\/jats:styled-content>), which also probably contribute to underlying inflammatory processes. Nuclear factor\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>(<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>) is a well\u2010known redox\u2010sensitive transcription factor that controls the genes responsible for regulating inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, the authors investigated the effect of short\u2010term salicylideneamino\u20102\u2010thiophenol (<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102) administration on the modulation of pro\u2010inflammatory<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>through redox regulation in aged rats. In addition, we compared the effects of<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 and caloric restriction (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) on inflammation and redox balance. The subjects were 24\u2010month\u2010old (old) Fischer 344 rats administered<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 (10\u2009mg\/kg\/day) by dietary supplementation or placed on a 30% restricted diet for 10\u2009days, and 6\u2010month\u2010old (young) rats fed ad libitum for 10\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>activation and the expressions of its related genes (vascular cell adhesion molecule\u20101, intercellular adhesion molecule\u20101, cyclooxygenase\u20102 and inducible nitric oxide synthase) were suppressed by<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 supplementation in old<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>rats to the levels observed in young rats. In addition, our molecular studies showed that the inhibitory effect of<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 on the activation of<jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010\u03ba<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>was mediated by the ability of<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 to block the nuclear translocations of cytosolic thioredoxin and redox factor\u20101.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings strongly indicate that<jats:styled-content style=\"fixed-case\">SAL<\/jats:styled-content>\u20102 stabilizes age\u2010related redox imbalance and modulates the signal transduction pathway involved in the age\u2010associated molecular inflammatory process.<jats:bold>Geriatr Gerontol Int 2015; 15: 211\u2013219.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12255","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T03:13:57Z","timestamp":1409195637000},"page":"211-219","source":"Crossref","is-referenced-by-count":2,"title":["Salicylideneamino\u20102\u2010thiophenol modulates nuclear factor\u2010\u03ba<scp>B<\/scp>through redox regulation during the aging process"],"prefix":"10.1111","volume":"15","author":[{"given":"Bokyung","family":"Sung","sequence":"first","affiliation":[{"name":"Molecular Inflammation Research Center for Aging Intervention (MRCA) Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seongjoon","family":"Park","sequence":"additional","affiliation":[{"name":"Molecular Inflammation Research Center for Aging Intervention (MRCA) Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Ha","sequence":"additional","affiliation":[{"name":"Molecular Inflammation Research Center for Aging Intervention (MRCA) Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Molecular Inflammation Research Center for Aging Intervention (MRCA) Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1183-7159","authenticated-orcid":false,"given":"Chan Hum","family":"Park","sequence":"additional","affiliation":[{"name":"Molecular Inflammation Research Center for Aging Intervention (MRCA) Pusan National University Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Jin","family":"Jung","sequence":"additional","affiliation":[{"name":"Korea Institute of Toxicology Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min 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