{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:47:40Z","timestamp":1791049660327,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24700775"],"award-info":[{"award-number":["24700775"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","award":["24249044"],"award-info":[{"award-number":["24249044"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology","doi-asserted-by":"crossref","award":["23-33"],"award-info":[{"award-number":["23-33"]}],"id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,3]]},"abstract":"\n Aim<\/jats:title>\n \n Sarcopenia accelerates frailty syndrome, and adversely affects activities of daily living and quality of life. The aim of the present study was to assess longitudinal relationships between baseline androgen and muscle mass changes in\n J<\/jats:styled-content>\n apanese women.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Data were collected from 539 community\u2010dwelling,\n J<\/jats:styled-content>\n apanese women aged 40\u201379\u2009years at baseline who participated in both baseline and follow\u2010up examinations of a longitudinal study of aging (mean duration 8.3\u2009years). Appendicular skeletal muscle mass was measured with dual\u2010energy\n X<\/jats:styled-content>\n \u2010ray absorptiometry at baseline and follow\u2010up examinations. The cut\u2010off point for sarcopenia was a skeletal muscle index (appendicular skeletal muscle mass\/height\n 2<\/jats:sup>\n ) <5.46\u2009kg\/m\n 2<\/jats:sup>\n . Participants with sarcopenia at baseline were excluded. Thus, 430 women were included. Total testosterone, free testosterone and dehydroepiandrosterone\u2010sulphate were measured by radioimmunoassay at baseline. The androgens were categorized into three groups by serum levels. Multiple logistic regression models were fit to determine the associations between androgens and sarcopenia while controlling for baseline age, body mass index, leisure\u2010time physical activity, nutritional intakes (total energy, total protein, vitamin\u2009\n D<\/jats:styled-content>\n ), serum\n C<\/jats:styled-content>\n \u2010reactive protein levels, medical histories (heart disease, osteoporosis, rheumatoid arthritis), menopause and smoking habit.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The fully adjusted odds ratio of sarcopenia for the low\u2010free testosterone group (<0.7\u2009pg\/mL) compared with the high\u2010free testosterone group (\u22651.2\u2009pg\/mL) was 3.59 (95% confidence interval 1.25\u201310.34). Sarcopenia was not significantly related to total testosterone or dehydroepiandrosterone\u2010sulphate.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n A low\u2010free testosterone level appears to be a significant predictor of the risk for loss of appendicular muscle in Japanese women.\n Geriatr Gerontol Int 2015; 15 326\u2013333.<\/jats:bold>\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ggi.12278","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T04:44:51Z","timestamp":1394772291000},"page":"326-333","source":"Crossref","is-referenced-by-count":29,"title":["Low free testosterone is associated with loss of appendicular muscle mass in\n J<\/scp>\n apanese community\u2010dwelling women"],"prefix":"10.1111","volume":"15","author":[{"given":"Atsumu","family":"Yuki","sequence":"first","affiliation":[{"name":"Faculty of Education Kochi University Kochi 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Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50216.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(98)00130-4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00334.2001"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-0312"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep01818"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.12.4476"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2007.03.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0702"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071851"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gln026"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afp015"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.2188\/jea.10.1sup_1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0581"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-010-1473-z"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.7600\/jpfsm.1.167"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.2740\/jisdh.20.203"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.6.1886"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/jcrc.2000.0150012"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02203.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.8.2832"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.2152\/jmi.59.12"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2007.51"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000485"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1693"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0785-y"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054629"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-013-0443-z"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.5.M409"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0212"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2063"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2134"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2011.04.014"}],"container-title":["Geriatrics 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