{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:54:05Z","timestamp":1780365245984,"version":"3.54.1"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study aimed to describe treatments, relative survival and prognostic factors in breast cancer patients according to age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All women with primary invasive breast cancer, diagnosed from 1998 to 2009 in the department of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u00f4te d'<jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>r, were retrospectively selected. Variations in treatments administered according to age (&lt;50\u2009years, 50\u201374\u2009years, &gt;74\u2009years) and period were assessed using <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ochran\u2013<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>rmitage trend tests and \u03c7<jats:sup>2<\/jats:sup>\u2010tests, respectively. Prognostic factors according to age were estimated using a generalized linear model with a Poisson error structure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 4305 women were included. The oldest women (aged &gt;74\u2009years) were more likely than the youngest women to have comorbidities, advanced stage tumors, hormone receptor\u2010positive tumors and be human epidermal growth factor receptor\u20092\u2010negative. The use of breast conserving surgery plus adjuvant therapy decreased in older women (&gt;74\u2009years), whereas the proportions of women without treatments and with adjuvant hormone therapy increased with age. Multivariate relative survival analyses according to age showed an increased risk of death in women aged 50\u201374\u2009years and &gt;74\u2009years with comorbidities compared with those without comorbidities; relative excess risks were 1.85 (1.13\u20133.02) and 3.23 (1.26\u20138.31), respectively. In contrast, a decreased risk of death was observed in women aged 50\u201374\u2009years diagnosed by medical imaging compared with those diagnosed by clinical signs; relative excess risks 0.44 (0.22\u20130.89).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elderly women compared with the youngest women were diagnosed with more favorable tumor biology (hormone receptor\u2010positive tumors, human epidermal growth factor receptor\u20092\u2010negative). However, survival was poor in elderly women who had comorbid conditions, did not attend screening mammography examinations and were undertreated. <jats:bold>Geriatr <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>erontol <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nt 2015; 15: 617\u2013626.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12327","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T23:15:38Z","timestamp":1422573338000},"page":"617-626","source":"Crossref","is-referenced-by-count":14,"title":["In breast cancer, are treatments and survival the same whatever a patient's age? A population\u2010based study over the period 1998\u20132009"],"prefix":"10.1111","volume":"15","author":[{"given":"Pegdwende Olivia","family":"Dialla","sequence":"first","affiliation":[{"name":"Breast and Gynaecologic Cancer Registry of C\u00f4te d'Or Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"},{"name":"EA 4184 Faculty of Medicine University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Quipourt","sequence":"additional","affiliation":[{"name":"Coordination Unit in Geriatric Oncology in Burgundy H\u00f4pital de jour G\u00e9riatrique H\u00f4pital de Champmaillot  Dijon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Gentil","sequence":"additional","affiliation":[{"name":"Breast and Gynaecologic Cancer Registry of C\u00f4te d'Or Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"},{"name":"EA 4184 Faculty of Medicine University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Marilier","sequence":"additional","affiliation":[{"name":"Coordination Unit in Geriatric Oncology in Burgundy H\u00f4pital de jour G\u00e9riatrique H\u00f4pital de Champmaillot  Dijon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Laure","family":"Poillot","sequence":"additional","affiliation":[{"name":"Breast and Gynaecologic Cancer Registry of C\u00f4te d'Or Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"},{"name":"EA 4184 Faculty of Medicine University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Roignot","sequence":"additional","affiliation":[{"name":"Pathology Centre  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Altwegg","sequence":"additional","affiliation":[{"name":"Radiotherapy Centre of Park  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariane","family":"Darut\u2010Jouve","sequence":"additional","affiliation":[{"name":"Private Hospital Cl\u00e9ment\u2010Drevon  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9v\u00e9rine","family":"Guiu","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Arveux","sequence":"additional","affiliation":[{"name":"Breast and Gynaecologic Cancer Registry of C\u00f4te d'Or Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"},{"name":"EA 4184 Faculty of Medicine University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tienhan Sandrine","family":"Dabakuyo\u2010Yonli","sequence":"additional","affiliation":[{"name":"Biostatistics and Quality of Life Unit Centre Georges Fran\u00e7ois Leclerc Comprehensive Cancer Centre  Dijon Cedex France"},{"name":"EA 4184 Faculty of Medicine University of Burgundy  Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.10.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2008.03.117"},{"key":"e_1_2_7_4_1","unstructured":"INCA.La situation du cancer en France en 2011. Collection Rapports et synth\u00e8ses ouvrage collectif \u00e9dit\u00e9 par l'INCa Boulogne\u2010Billancourt 2011."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11226"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00283-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980831)77:5<679::AID-IJC3>3.0.CO;2-S"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20038"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.330.7485.205"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802167482"},{"key":"e_1_2_7_11_1","volume-title":"Cancers: \u00c9valuation, Traitement Et Surveillance","author":"Andrieu JM","year":"1997"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2010.02.022"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-0898-8"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601844"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601662"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1012974728007"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.02.029"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm491"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-004-1470-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12069"},{"key":"e_1_2_7_21_1","volume-title":"International Union Against Cancer (UICC): TNM Classification of Malignant Tumors","author":"Sobin LH","year":"1997"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1597"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-383"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.02.046"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.9796"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70245-0"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27857"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12059"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2005.04.008"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2215-1"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2012.05.031"},{"key":"e_1_2_7_32_1","first-page":"272","article-title":"Survival of women with breast cancer in Kaunas region, Lithuania","volume":"48","author":"Ivanauskiene R","year":"2012","journal-title":"Medicina (Kaunas)"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn711"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq191"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2011.03.001"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/RNJ.00013"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fggi.12327","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.12327","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:30:33Z","timestamp":1695569433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.12327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,11]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1111\/ggi.12327"],"URL":"https:\/\/doi.org\/10.1111\/ggi.12327","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,11]]}}}