{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:32:45Z","timestamp":1759091565659},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T00:00:00Z","timestamp":1407715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Aim<\/jats:title>Personal mastery has been associated with physical function maintenance later in life. Less is known about the relationship between lack of personal mastery and functional decline in A<\/jats:styled-content>sian populations, and whether multisystem physiological dysregulation explains this relationship.<\/jats:p><\/jats:sec>Methods<\/jats:title>Participants (n<\/jats:italic>\u2009=\u2009487) from the S<\/jats:styled-content>ocial E<\/jats:styled-content>nvironment and B<\/jats:styled-content>iomarkers of A<\/jats:styled-content>ging S<\/jats:styled-content>tudy, a population\u2010based prospective cohort study in T<\/jats:styled-content>aiwan, received baseline measurements of personal mastery using the P<\/jats:styled-content>earlin M<\/jats:styled-content>astery S<\/jats:styled-content>cale. Multisystem physiological dysregulation at baseline was assessed as a summary score based on the levels of 16 biomarkers of the hypothalamic\u2013pituitary\u2013adrenal axis, the sympathetic nervous system, the cardiovascular system, the metabolic system and the immune system functioning. Function in activities of daily living was determined at baseline and at a 7\u2010year follow up.<\/jats:p><\/jats:sec>Results<\/jats:title>Participants in the lowest quartile of the personal mastery score were more likely to experience functional decline than those in the higher quartiles (OR<\/jats:styled-content> comparing the lowest with highest 3 quartiles 2.99, 95% CI<\/jats:styled-content> 1.71\u20135.21). After adjusting for confounders, personal mastery remained significantly associated with functional changes (adjusted OR<\/jats:styled-content> 2.09, 95% CI<\/jats:styled-content> 1.05\u20134.14). Greater sense of personal mastery was associated with significantly less multisystem physiological dysregulation (P<\/jats:italic> for trend\u2009=\u20090.001). When the levels of physiological dysregulation were added to the multivariate models, the association between a poor sense of personal mastery and functional decline was attenuated.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Lack of personal mastery is independently associated with an increased risk of functional decline in older adults. Multisystem physiological dysregulation partially explains this relationship. Geriatr Gerontol Int 2015; 15: 707\u2013714.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12334","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T23:20:34Z","timestamp":1422573634000},"page":"707-714","source":"Crossref","is-referenced-by-count":6,"title":["Personal mastery, multisystem physiological dysregulation and risk of functional decline in older adults: A prospective study in T<\/scp>aiwan"],"prefix":"10.1111","volume":"15","author":[{"given":"I\u2010Chien","family":"Wu","sequence":"first","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes Miaoli County Taiwan"},{"name":"Program for Aging College of Medicine China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao A","family":"Hsiung","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u2010Shou","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research and Division of Biostatistics and Bioinformatics National Health Research Institutes Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Shiang","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes Miaoli County Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hung","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Public Health China Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Cheng","family":"Hsu","sequence":"additional","affiliation":[{"name":"Institute of Population Health Sciences National Health Research Institutes Miaoli County Taiwan"},{"name":"Department of Health Services Administration China Medical University and Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61594-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1997.tb00986.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61829-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136319"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2307\/2136676"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0278-6133.25.1.102"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e31815e6e9b"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1126\/science.3749877","article-title":"Aging and health: effects of the sense of control","volume":"233","author":"Rodin J","year":"1986","journal-title":"Science"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69746-8"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009305"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/58.4.S212"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/61.2.P95"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013297"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2009.02611.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/58.4.S221"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0023480"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409174102"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.081072698"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1997.00440400111013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2006.06.050"},{"key":"e_1_2_7_22_1","volume-title":"Survey of Health and Living Status of the Elderly in Taiwan: Questionnaire and Survey Design","author":"Hermalin AI","year":"1989"},{"key":"e_1_2_7_23_1","first-page":"250","volume-title":"Cells and Surveys: Should Biological Measures Be Included in Social Science Research?","author":"Weinstein M","year":"2001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(02)00580-2"},{"key":"e_1_2_7_25_1","unstructured":"GoldmanN WeinsteinM ChangM\u2010Cet\u2009al.Social environment and biomarkers of aging study (SEBAS) in Taiwan 2000 and 2006. 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