{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:32:19Z","timestamp":1761895939207},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T00:00:00Z","timestamp":1411689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to investigate whether older age leads to limitations in the starting dose of imatinib in daily treatment of chronic myeloid leukemia, and to determine the compliance of elderly patients with tyrosine kinase inhibitors (<jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>) therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data including the clinical characteristics, therapeutic outcomes and compliance with <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> therapy of elderly patients with chronic myeloid leukemia aged &gt;65\u2009years were collected from 13 institutions in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>urkey, retrospectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 69 patients (27 [39%] men, 42 [61%] women) were evaluated retrospectively. The median age of the patients was 71\u2009years (range 66\u201385\u2009years). Of the patients, 66 (96%) were in the chronic phase and three (4.3%) were in the accelerated phase when diagnosed. A total of 63 (91.3%) patients were receiving imatinib as the first\u2010line therapy. The initial dose of imatinib was 400\u2009mg\/day in 59 patients (93.6%). Imatinib treatment induced 57 (90.5%) complete hematological responses at 3\u2009months, 29 (46%) complete cytogenetic responses at 6\u2009months and 49 (77.7%) major molecular responses at 12\u2009months. As a result, nilotinib and dasatinib were used in 14 patients as second\u2010line therapy. Second\u2010line <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> induced nine complete hematological responses (64.3%) at 3\u2009months, four complete cytogenetic responses (28.6%) at 12\u2009months and seven major molecular responses (50%) at 18\u2009months. A total of 56 of the patients (81.2%) are still alive. The median overall survival and progression\u2010free survival rates were 35\u2009months (range 1\u201395\u2009months) and 17\u2009months (range 0.8\u201395\u2009months), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elderly patients should receive <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> according to the same guidelines that apply to younger patients. <jats:bold>Geriatr Gerontol Int 2015; 15: 729\u2013735.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12341","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T05:26:38Z","timestamp":1411709198000},"page":"729-735","source":"Crossref","is-referenced-by-count":3,"title":["Clinical characteristics and therapeutic outcomes of elderly patients with chronic myeloid leukemia: A retrospective multicenter 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