{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T02:01:38Z","timestamp":1722909698221},"reference-count":42,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T00:00:00Z","timestamp":1413244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>The present study aimed to evaluate the relationship between the change of carotid intima\u2010media thickness (<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>) and clinical characteristics in <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients without a history of cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study participants were 149 <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients without a history of cardiovascular disease treated in our outpatient department. The in all participants <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> was measured with ultrasonography at baseline and after a mean interval of 2.4 years. Study participants were divided into a middle\u2010aged group (younger than 65 years: <jats:italic>n<\/jats:italic>\u2009=\u200959) and an elderly group (65 years or older: <jats:italic>n<\/jats:italic>\u2009=\u200990). The annual <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> change (\u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content>) was calculated, and the associations between \u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> and clinical characteristics, including age, were evaluated in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The \u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> was significantly correlated with age in all participants (<jats:italic>r<\/jats:italic>\u2009=\u20090.222; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and in elderly participants (r\u2009=\u20090.234; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), but was not correlated with other risk factors. The annual \u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> was significantly higher in elderly participants (0.015\u2009\u00b1\u20090.096\u2009mm) than in middle\u2010aged participants (\u20130.018\u2009\u00b1\u20090.088\u2009mm; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Multivariate linear regression analysis with \u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> as a dependent variable and risk factors as independent variables showed that \u0394<jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> was significantly associated with age in all participants (\u03b2\u2009=\u20090.002; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05) and in elderly participants (\u03b2\u2009=\u20090.004; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), but not with other risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Annual <jats:styled-content style=\"fixed-case\">CIMT<\/jats:styled-content> change is associated with age, rather than with other clinical characteristics, including traditional cardiovascular risk factors, such as diabetes and hypertension, in elderly <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>apanese patients without a history of cardiovascular disease. <jats:bold>Geriatr Gerontol Int 2015; 15: 1023\u20131030.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12402","type":"journal-article","created":{"date-parts":[[2014,10,14]],"date-time":"2014-10-14T10:13:00Z","timestamp":1413281580000},"page":"1023-1030","source":"Crossref","is-referenced-by-count":6,"title":["Change of carotid intima\u2010media thickness is associated with age in elderly <scp>J<\/scp>apanese patients without a history of cardiovascular disease"],"prefix":"10.1111","volume":"15","author":[{"given":"Kentaro","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED) Yamagata University Faculty of Medicine  Yamagata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoshi","family":"Ouchi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology Dokkyo Medical University School of Medicine  Tochigi 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