{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:07:46Z","timestamp":1780963666070,"version":"3.54.1"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T00:00:00Z","timestamp":1414972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Daiichi Sankyo Co. Ltd."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Although recent studies suggest that several antihypertensive drugs could reduce the risk of bone fracture, it is still unclear how these drugs act on bone remodeling, especially in elderly women with severe osteoporosis with disuse syndrome. In the present study, we investigated the effects of a calcium channel blocker (<jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content>) and an angiotensin\u2009<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> receptor blocker (<jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content>) on bone metabolism in elderly bedridden women with hypertension and disuse syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Elderly bedridden women (aged &gt;75 years) receiving antihypertensive therapy treated with <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> were recruited in the present study. The participants were divided into two groups \u2013 <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> group and <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> group \u2013 and followed up to 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Markers of bone resorption were markedly increased, suggesting accelerated bone resorption in the participants of the present study. In the follow\u2010up period, the patients treated with a <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> showed a significant decrease in bone mineral density in a time\u2010dependent manner, accompanied by a significant increase in bone resorption markers, whereas treatment with olmesartan inhibited bone loss, associated with attenuation of increased bone resorption markers. Bone mineral density of femoral neck in the <jats:styled-content style=\"fixed-case\">CCB<\/jats:styled-content> group was significantly lower than that in the <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> group at 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study showed inhibitory effects of an <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> on bone resorption in hypertensive patients with accelerated bone resorption, such as elderly bedridden women, and indicated an important role of the renin\u2013angiotensin system in bone metabolism. In elderly hypertensive patients, <jats:styled-content style=\"fixed-case\">ARB<\/jats:styled-content> might be expected to have additional beneficial potential to maintain bone health in bedridden patients. <jats:bold>Geriatr Gerontol Int 2015; 15: 1064\u20131072.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12406","type":"journal-article","created":{"date-parts":[[2014,11,3]],"date-time":"2014-11-03T10:06:10Z","timestamp":1415009170000},"page":"1064-1072","source":"Crossref","is-referenced-by-count":22,"title":["Effect of angiotensin\u2009<scp>II<\/scp> receptor blocker, olmesartan, on turnover of bone metabolism in bedridden elderly hypertensive women with disuse syndrome"],"prefix":"10.1111","volume":"15","author":[{"given":"Motokuni","family":"Aoki","sequence":"first","affiliation":[{"name":"Graduate School of Health Sciences Morinomiya University of Medical Sciences  Osaka 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