{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:17:42Z","timestamp":1789449462853,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,2,5]],"date-time":"2015-02-05T00:00:00Z","timestamp":1423094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Science, Culture and Sports of Japan","doi-asserted-by":"crossref","award":["21390267"],"award-info":[{"award-number":["21390267"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Research Committee of CNS Degenerative Diseases"},{"name":"Ministry of Health, Labor and Welfare of Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Objects<\/jats:title>A<\/jats:styled-content>lzheimer's disease (AD<\/jats:styled-content>) is one of the most important diseases in aging society, and non\u2010drug therapy might be an alternative therapeutic approach. Thus, we evaluated the add\u2010on effect of cognitive rehabilitation on AD<\/jats:styled-content> patients under donepezil treatment.<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively analyzed 55 AD<\/jats:styled-content> patients with a M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination score of 15\u201325, dividing them into two groups depending on whether they were receiving ambulatory cognitive rehabilitation (group D<\/jats:styled-content>\u2009+\u2009R<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200932) or not (group D<\/jats:styled-content>, n<\/jats:italic>\u2009=\u200923) in K<\/jats:styled-content>urashiki H<\/jats:styled-content>eisei H<\/jats:styled-content>ospital over 1 year. The present cognitive rehabilitation included physical therapy, occupational therapy and speech therapy for 1\u20132\u2009h once or twice a week.<\/jats:p><\/jats:sec>Results<\/jats:title>Between group\u2009D<\/jats:styled-content> and group\u2009D<\/jats:styled-content>\u2009+\u2009R<\/jats:styled-content>, there was no significant difference in baseline data, such as age, M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination score, periventricular hyperintensity on magnetic resonance imaging, deep white matter hyperintensity on magnetic resonance imaging or donepezil dose (4.1\u2009mg\/day). At 1 year later, however, the M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination score improved only in group D<\/jats:styled-content>\u2009+\u2009R<\/jats:styled-content> from 21.7 to 24.0 (**P<\/jats:italic>\u2009<\u20090.001), whereas that of group\u2009D<\/jats:styled-content> remained at 21.5 with both groups of donepezil 5.0\u2009mg\/day.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The combination of cognitive rehabilitation plus a choline esterase inhibitor donepezil showed a better effect for the cognitive function of AD<\/jats:styled-content> patients than drug only therapy at 1 year. Geriatr Gerontol Int 2016; 16: 200\u2013204.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12455","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T04:57:11Z","timestamp":1423198631000},"page":"200-204","source":"Crossref","is-referenced-by-count":16,"title":["Combination benefit of cognitive rehabilitation plus donepezil for A<\/scp>lzheimer's disease patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Kosuke","family":"Matsuzono","sequence":"first","affiliation":[{"name":"Department of Neurology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical science Okayama Japan"},{"name":"Department of Neurology Kurashiki Heisei Hospital Kurashiki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nozomi","family":"Hishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical science Okayama 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