{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T07:16:41Z","timestamp":1773386201853,"version":"3.50.1"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify the prevalence of onychomycosis and epidemiological features in older adults (&gt;65%) with toenail onychodystrophy. In particular, the aim of the study was to analyze risk factors\/protective factors, clinical manifestations, comorbidities and etiological agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was carried out from <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ebruary 2012 to <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ay 2012 at <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>an <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>artino\u2010<jats:styled-content style=\"fixed-case\">IST<\/jats:styled-content> of Genoa, Italy. The inclusion criteria for enrolment were the presence of onychodystrophy of one or more toenails and age &gt;65\u2009years. The exclusion criteria were systemic\/topical antifungal treatments in the previous 6\u2009months, drilling of the nail plate in the previous 6\u2009months and a specialist's diagnosis or suspicion of onychomycosis. A database was created for the patients' anamnesis, the clinics and testing results. Several statistical analyses were carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 100 patients fulfilled the inclusion criteria. A total of 35 cases had positive results, and the etiological agent was isolable in 14 cases. The most represented was <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>richophyton mentagrophytes<\/jats:italic> followed by <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>richophyton rubrum<\/jats:italic> and others. Multivariate logistic regression analysis showed the significant roles of sex and diabetes as risk factors, and the use of statins as a protective factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Onychomycosis has a high prevalence in older adults with onychodystrophy. It is important not to overlook onychodystrophy, and to carry out laboratory testing to exclude a fungal infection. In fact, as older patients often cannot undergo systemic antifungal therapies, it is fundamental to treat them early and avoid the spread of infection. <jats:bold>Geriatr Gerontol Int 2016; 16: 486\u2010491.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12496","type":"journal-article","created":{"date-parts":[[2015,5,16]],"date-time":"2015-05-16T00:04:18Z","timestamp":1431734658000},"page":"486-491","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiological study of onychomycosis in older adults with onychodystrophy"],"prefix":"10.1111","volume":"16","author":[{"given":"Emanuele","family":"Cozzani","sequence":"first","affiliation":[{"name":"DISSAL\u2010University of Genoa\u2010IRCCS Section of Dermatology AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna Fay","family":"Agnoletti","sequence":"additional","affiliation":[{"name":"DISSAL\u2010University of Genoa\u2010IRCCS Section of Dermatology AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Speziari","sequence":"additional","affiliation":[{"name":"School of Podiatry University of Genoa AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Schiavetti","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Department of Health Sciences University of Genoa  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirca","family":"Zotti","sequence":"additional","affiliation":[{"name":"Department of Enviroment, Earth, and Life Science (DISTAV) Laboratory of Mycology Corso Dogali  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Persi","sequence":"additional","affiliation":[{"name":"DISSAL\u2010University of Genoa\u2010IRCCS Section of Dermatology AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Drago","sequence":"additional","affiliation":[{"name":"DISSAL\u2010University of Genoa\u2010IRCCS Section of Dermatology AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Parodi","sequence":"additional","affiliation":[{"name":"DISSAL\u2010University of Genoa\u2010IRCCS Section of Dermatology AUO San Martino\u2010IST  Genoa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"3","article-title":"An observational and descriptive study of the epidemiology of and therapeutic approach to onychomycosis in dermatology offices in Brazil","volume":"88","author":"Di Chiacchio N","year":"2013","journal-title":"An Bras Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12088"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.12788\/j.sder.0014"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2007.00310.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01282.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2004.01066.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-13-68"}],"container-title":["Geriatrics &amp; Gerontology International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fggi.12496","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ggi.12496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T09:52:15Z","timestamp":1695549135000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ggi.12496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,15]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/ggi.12496"],"URL":"https:\/\/doi.org\/10.1111\/ggi.12496","archive":["Portico"],"relation":{},"ISSN":["1444-1586","1447-0594"],"issn-type":[{"value":"1444-1586","type":"print"},{"value":"1447-0594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,15]]}}}