{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T16:25:59Z","timestamp":1751300759747},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Analysis of the characteristics of very elderly patients with giant cell arteritis (<jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients aged 80 years and older diagnosed with <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> in our department between 1 January 2002 and 31 July 2008 were retrospectively included. For each patient, we recorded general characteristics, reason(s) for hospitalization, specialty of the physician or department that referred the patient to us, medical history, treatment at admission, <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> clinical features, time to diagnosis of <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content>, biological screening and <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 25 clinical records, 18 women and seven men with a mean age of 83.9 years. General weakness, visual loss and inflammatory syndrome were the principal reasons for hospitalization. Patients were mainly referred by general practitioners or ophthalmological departments. At diagnosis, headache and musculoskeletal disorders were the most frequent signs (52% each), before general weakness and visual disorders. Time to diagnosis was 2.2 months. Inflammatory syndrome was very frequent (92%). Biopsy of the temporal artery confirmed <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> in 16 cases. Corticosteroid therapy (<jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content>) mean dose was 0.9\u2009mg\/kg\/day. Because of the positive evolution, <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> was stopped in nine patients after 22.7\u2009\u00b1\u200915 months. A total of 22 patients received a preventive osteoporosis treatment. After 3 months of <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content>, clinical signs and <jats:styled-content style=\"fixed-case\">IS<\/jats:styled-content> vanished in 22 patients. <jats:styled-content style=\"fixed-case\">CST<\/jats:styled-content> complications, mainly infection, appeared in 17 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical and biological features of <jats:styled-content style=\"fixed-case\">GCA<\/jats:styled-content> in the very elderly patients of the present study were comparable with those described in the literature in younger patients. However, it must be pointed out that our patients were not compared with a younger population in this study. <jats:bold>Geriatr Gerontol Int 2015; \u25cf\u25cf: \u25cf\u25cf\u2013\u25cf\u25cf.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12536","type":"journal-article","created":{"date-parts":[[2015,6,17]],"date-time":"2015-06-17T02:55:06Z","timestamp":1434509706000},"page":"679-685","source":"Crossref","is-referenced-by-count":4,"title":["Giant cell arteritis (<scp>H<\/scp>orton's disease) in very elderly patients aged 80 years and older: A study of 25 cases"],"prefix":"10.1111","volume":"16","author":[{"given":"G\u00e9raldine","family":"Muller","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Systemic Diseases University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Devilliers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Systemic Diseases University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Besancenot","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Systemic Diseases University Hospital  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Manckoundia","sequence":"additional","affiliation":[{"name":"Department of Geriatrics and Internal Medicine Hospital of Champmaillot University Hospital  Dijon France"},{"name":"Inserm\/U1093 Motricity\u2010Plasticity University of Burgundy  Dijon France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,16]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","first-page":"SII79","article-title":"Epidemiology of giant\u2010cell arteritis","volume":"69","author":"Hunder GG","year":"2002","journal-title":"Cleve Clin J Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780240706"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra011913"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.111005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20227"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-97-5-672"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780330810"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.md.0000180042.42156.d1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0307-742X(21)00303-9"},{"key":"e_1_2_7_11_1","first-page":"373","article-title":"Maladie de Horton chez le sujet \u00e2g\u00e9 de plus de 75 ans","volume":"153","author":"Chevalet P","year":"2002","journal-title":"Ann Med Interne (Paris)"},{"issue":"237","key":"e_1_2_7_12_1","first-page":"1","article-title":"An arteritis with special reference to polymyalgia arteritica","volume":"237","author":"Ostberg G","year":"1973","journal-title":"Acta Pathol Microbiol Scand Suppl"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6845.68"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2005.06.011"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(99)80193-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00770-7"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200104)45:2<140::AID-ANR166>3.0.CO;2-2"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1259::AID-ANR24>3.0.CO;2-I"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11480"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2009.04.001"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(03)00228-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.85.9.1061"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.11388"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.45.2.136"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10262"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker296"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.149351"}],"container-title":["Geriatrics &amp; 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