{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T19:58:49Z","timestamp":1770235129041,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T00:00:00Z","timestamp":1433376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>deficiency is frequent in older patients, and the main reason is pernicious anemia. However, vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>deficiency can occur in patients who do not have atrophic gastritis. The aim of the present study was to investigate factors affecting serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>levels in older patients with non\u2010atrophic gastritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1256 out of 1607 patients aged over 60 years who had undergone upper gastrointestinal endoscopy for various reasons, and who had serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>value and were diagnosed as having \u201cnon\u2010atrophic gastritis\u201d were analyzed by means of factors affecting low serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010atrophic gastritis patients were divided into two groups: patients with normal serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>(group\u2009<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>,<jats:italic>n<\/jats:italic>\u2009=\u2009759) and patients with low serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>(group\u2009<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>,<jats:italic>n<\/jats:italic>\u2009=\u2009497). The median serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>was 339\u2009pg\/mL (range 201\u2013987\u2009pg\/mL) in group\u2009<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>and 180\u2009pg\/mL (range 50\u2013200\u2009pg\/mL) in group\u2009<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>.<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic>(<jats:italic>n<\/jats:italic>\u2009=\u2009154<jats:italic>vs<\/jats:italic>325,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), neutrophil activity (<jats:italic>n<\/jats:italic>\u2009=\u2009176<jats:italic>vs<\/jats:italic>367,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), intestinal metaplasia (<jats:italic>n<\/jats:italic>\u2009=\u200935<jats:italic>vs<\/jats:italic>14,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and inflammation (<jats:italic>n<\/jats:italic>\u2009=\u2009230<jats:italic>vs<\/jats:italic>386,<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) were present significantly more often in group\u2009<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>compared with group<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>. A total of 785 patients were both negative for<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic>and atrophy. Of these 785 patients, neutrophil activity (<jats:italic>n<\/jats:italic>\u2009=\u200956, [32.6%]<jats:italic>vs<\/jats:italic>25, [4.4%],<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and inflammation (<jats:italic>n<\/jats:italic>\u2009=\u200969, [40.1%]<jats:italic>vs<\/jats:italic>82, [13.4%],<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) scores were present significantly more often in group\u2009<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>compared with group\u2009<jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic>was present significantly more often in older patients whose serum vitamin\u2009<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>levels were \u2264200\u2009pg\/mL, and<jats:styled-content style=\"fixed-case\"><jats:italic>H<\/jats:italic><\/jats:styled-content><jats:italic>elicobacter pylori<\/jats:italic>density was inversely correlated with serum<jats:styled-content style=\"fixed-case\">B<\/jats:styled-content><jats:sub>12<\/jats:sub>level. Upper gastrointestinal endoscopic examination should be suggested for elderly patients with serum vitamin\u2009B<jats:sub>12<\/jats:sub>level \u2264200\u2009pg\/mL.<jats:bold>Geriatr Gerontol Int 2015; \u25cf\u25cf: \u25cf\u25cf\u2013\u25cf\u25cf.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12537","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T03:56:41Z","timestamp":1433476601000},"page":"686-692","source":"Crossref","is-referenced-by-count":11,"title":["Factors related to low serum vitamin\u2009<scp>B<\/scp><sub>12<\/sub>levels in elderly patients with non\u2010atrophic gastritis in contrast to patients with normal vitamin\u2009<scp>B<\/scp><sub>12<\/sub>levels"],"prefix":"10.1111","volume":"16","author":[{"given":"\u00c7a\u011fda\u015f","family":"Kalkan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ibni Sina Hospital Ankara University Faculty of Medicine Ankara 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