{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:33:21Z","timestamp":1775792001123,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to identify the relationship between regional cerebral blood flow (<jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>) and error types on the Clock Drawing Test (<jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content>) in patients with Alzheimer's disease (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> was administered to 142 patients with <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. We used the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>endez scoring method. Their <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> values were measured by single\u2010photon emission computed tomography. The correlation between the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> total score and <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> was examined on a voxel\u2010by\u2010voxel basis. After we excluded 37 patients whose drawings were inappropriate for assessing the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> error types, we examined the relationships between each error type on the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total score on the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> was positively correlated with <jats:styled-content style=\"fixed-case\">rCBF<\/jats:styled-content> in the left posterior middle temporal lobe. We also found relationships between the error \u201cnon\u2010existence of number 2, or not pointing toward number 2\u201d and the left frontal lobe; the error \u201cuneven number spacing\u201d and the bilateral frontal lobe; \u201cdeviation of the clock center\u201d and the left frontal lobe; \u201cmissing numbers\u201d and the right parietal lobe; \u201cuneven number distance from edge\u201d and the right parietal and the temporal lobes; \u201csame length hands\u201d and the bilateral temporal lobe; and \u201cunclosed circle\u201d and the left temporal lobe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Each error type on the <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> appears to relate to a different brain region. These findings will be useful in the understanding of <jats:styled-content style=\"fixed-case\">CDT<\/jats:styled-content> performances and the underlying neuropsychological pathology. <jats:bold>Geriatr Gerontol Int 2016; 16: 777\u2013784.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12550","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T16:24:47Z","timestamp":1436891087000},"page":"777-784","source":"Crossref","is-referenced-by-count":11,"title":["Neuroanatomical correlates of error types on the Clock Drawing Test in <scp>A<\/scp>lzheimer's disease patients"],"prefix":"10.1111","volume":"16","author":[{"given":"Hirotaka","family":"Nakashima","sequence":"first","affiliation":[{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Umegaki","sequence":"additional","affiliation":[{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeko","family":"Makino","sequence":"additional","affiliation":[{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Radiological and Medical Laboratory Sciences Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Radiological Technology Nagoya University Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Comprehensive Community Care Systems Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahumi","family":"Kuzuya","sequence":"additional","affiliation":[{"name":"Department of Community Healthcare and Geriatrics Nagoya University Graduate School of Medicine  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000203344"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000079198"},{"key":"e_1_2_7_4_1","first-page":"9","volume-title":"Clock Drawing: A neuropsychological analysis","author":"Freedman 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