{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:54:51Z","timestamp":1759964091582},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,5]],"date-time":"2015-08-05T00:00:00Z","timestamp":1438732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Aim<\/jats:title>The aim of the present study was to evaluate the relationship between baseline white matter lesions (WML<\/jats:styled-content>) and changes in regional cerebral blood flow during longitudinal follow up of patients with A<\/jats:styled-content>lzheimer's disease (AD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 38 patients with AD<\/jats:styled-content> were included in the study (16 men, 22 women; mean age 77.8 years). All patients were evaluated using the M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination and brain perfusion single\u2010photon emission computed tomography at baseline with an approximately 2\u2010year follow up. The patients were divided into two subgroups according to the presence of WML<\/jats:styled-content> on magnetic resonance imaging. Single\u2010photon emission computed tomography data were analyzed using a voxel\u2010by\u2010voxel group analysis with Statistical Parametric Mapping 8 and region of interest analysis using FineSRT<\/jats:styled-content>. Changes in M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination scores and regional cerebral blood flow were analyzed using the Wilcoxon signed\u2010rank test.<\/jats:p><\/jats:sec>Results<\/jats:title>Mean M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate E<\/jats:styled-content>xamination scores in AD<\/jats:styled-content> patients with WML<\/jats:styled-content> significantly decreased from 19.4\u2009\u00b1\u20094.8 to 15.5\u2009\u00b1\u20096.5 (P<\/jats:italic>\u2009=\u20090.003). Statistical Parametric Mapping 8 and FineSRT<\/jats:styled-content> analysis showed more severe and widespread regional cerebral blood flow reduction, mainly in the frontal and mesial temporal regions in AD<\/jats:styled-content> patients with WML<\/jats:styled-content> compared with those without WML<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Baseline WML<\/jats:styled-content> could predict a rapid progression of cognitive and brain functional impairment during longitudinal follow up in AD<\/jats:styled-content>. Geriatr Gerontol Int 2016; 16: 836\u2013842.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12563","type":"journal-article","created":{"date-parts":[[2015,8,6]],"date-time":"2015-08-06T02:53:12Z","timestamp":1438829592000},"page":"836-842","source":"Crossref","is-referenced-by-count":15,"title":["Relationship between white matter lesions and regional cerebral blood flow changes during longitudinal follow up in A<\/scp>lzheimer's disease"],"prefix":"10.1111","volume":"16","author":[{"given":"Takuya","family":"Hanaoka","sequence":"first","affiliation":[{"name":"Department of Neurology Faculty of Medicine Oita University Oita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology Faculty of Medicine Oita University Oita 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