{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:19:24Z","timestamp":1790824764501,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T00:00:00Z","timestamp":1450224000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007312","name":"National Center for Geriatrics and Gerontology (NCGG)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007312","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2015,12]]},"abstract":"Aims<\/jats:title>We determined whether the possible roles of oxidative stress differ in the pathophysiology and cognitive decline of A<\/jats:styled-content>lzheimer's disease (AD<\/jats:styled-content>), vascular dementia (VaD<\/jats:styled-content>) and mixed A<\/jats:styled-content>lzheimer's\/vascular dementia (MD<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We measured the levels of diacron reactive oxygen metabolite (dROM<\/jats:styled-content>), reflecting the amount of organic hydroperoxides, and biological anti\u2010oxidant potential (BAP), measuring the ferric reducing ability of blood plasma, in 72 patients with AD<\/jats:styled-content>, 27 with VaD<\/jats:styled-content>, 24 with MD<\/jats:styled-content> and 53 non\u2010demented outpatients (control group). In addition, endogenous plasma anti\u2010oxidants, such as albumin, total bilirubin and uric acid, were compared among the groups. All participants with VaD<\/jats:styled-content> and MD<\/jats:styled-content> showed extensive white matter hyperintensity, in addition to multiple lacunes.<\/jats:p><\/jats:sec>Results<\/jats:title>The dROM<\/jats:styled-content> levels were significantly higher in the AD<\/jats:styled-content> and MD<\/jats:styled-content> groups than in the control group. The BAP levels were significantly lower in the MD<\/jats:styled-content> group than in the control, AD<\/jats:styled-content> and VaD<\/jats:styled-content> groups. The AD<\/jats:styled-content> group showed significantly lower levels of bilirubin and uric acid than the control group. The MD<\/jats:styled-content> group showed a significantly lower level of albumin than the control and AD<\/jats:styled-content> groups, and a significantly lower level of bilirubin than the control group. The M<\/jats:styled-content>ini\u2010M<\/jats:styled-content>ental S<\/jats:styled-content>tate examination scores correlated significantly with dROM<\/jats:styled-content> levels and BAP\/dROM<\/jats:styled-content> ratios in the AD<\/jats:styled-content> group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>An imbalance in pro\u2010oxidant and anti\u2010oxidant defenses is apparently involved in the pathophysiology of the AD<\/jats:styled-content> and MD<\/jats:styled-content> groups. The extent of oxidative stress damage might differ in subtypes of dementia by being greater in the MD<\/jats:styled-content> group than in other types of dementia. Synergic effects of the degenerative element of AD<\/jats:styled-content> and white matter lesions might be associated with oxidative stress damage in the MD<\/jats:styled-content> group. Geriatr Gerontol Int 2015; (Suppl. 1): 53\u201358.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12659","type":"journal-article","created":{"date-parts":[[2015,12,16]],"date-time":"2015-12-16T08:55:54Z","timestamp":1450256154000},"page":"53-58","source":"Crossref","is-referenced-by-count":42,"title":["Differences in peripheral oxidative stress markers in A<\/scp>lzheimer's disease, vascular dementia and mixed dementia patients"],"prefix":"10.1111","volume":"15","author":[{"given":"Hirokuni","family":"Hatanaka","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruo","family":"Hanyu","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raita","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of 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