{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T07:14:24Z","timestamp":1776842064731,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T00:00:00Z","timestamp":1461542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korean government (MSIP)","award":["2014M3C7A1064752"],"award-info":[{"award-number":["2014M3C7A1064752"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Memantine is known to be effective in the treatment of the behavioral symptoms of dementia, especially agitation in moderate to severe Alzheimer's disease (AD). However, memantine and rivastigmine patch combination therapy has not been well studied in determining treatment effectiveness with mild to moderate AD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter, 24\u2010week, prospective, randomized, open\u2010label study design. A total 147\u2009AD patients with Mini\u2010Mental State Examination scores from 10 to 20 were randomly assigned to rivastigmine patch monotherapy and combination therapy with memantine groups. Agitation symptoms, using the Korean Version of the Cohen Mansfield Agitation Inventory were evaluated at baseline and at study end. Suppression and emergence of agitation symptoms were also evaluated. We carried out factor analyses to evaluate the interrelationship of agitation symptoms and to investigate treatment response in these symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Factor analyses showed two symptom clusters: factor A \u2013 aggressive agitated behaviors \u2013 versus factor B \u2013 non\u2010aggressive agitated behaviors. The rivastigmine patch monotherapy group showed significantly decreased factor B scores and had a tendency of decreased Korean Version of the Cohen Mansfield Agitation Inventory total scores and factor A scores. Conversely, the combination therapy group showed significantly increased Korean Version of the Cohen Mansfield Agitation Inventory total scores and factor B scores. Neither monotherapy nor combination therapy reduced the emergence of new agitation symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this trial of mild to moderate AD patients, the rivastigmine patch monotherapy group experienced a reduction of non\u2010aggressive agitated behaviors. However, combination therapy with memantine did not show any benefit on the agitation associated with mild to moderate AD. <jats:bold>Geriatr Gerontol Int 2017; 17: 494\u2013499.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12754","type":"journal-article","created":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T17:39:30Z","timestamp":1461692370000},"page":"494-499","source":"Crossref","is-referenced-by-count":10,"title":["Effects on agitation with rivastigmine patch monotherapy and combination therapy with memantine in mild to moderate Alzheimer's disease: a multicenter 24\u2010week prospective randomized open\u2010label study (the Korean EXelon Patch and combination with mEmantine Comparative Trial study)*"],"prefix":"10.1111","volume":"17","author":[{"given":"Soo J","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Neurology Eulji University Hospital, Eulji University School of Medicine  Daejeon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong H","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University Hospital, Inha University School of Medicine  Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae R","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology Bobath Memorial Hospital  Seongnam\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Won","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology Dong\u2010A Medical Center, Dong\u2010A University College of Medicine  Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun\u2010Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute  Pusan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun J","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Neurology Myongji Hospital, Seonam University of College of Medicine  Goyang Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Hong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Asan Medical Center, University of Ulsan College of Medicine  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young S","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Neurology Bucheon St. Mary's Hospital, The Catholic University College of Medicine  Bucheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duk L","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul 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