{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:31:04Z","timestamp":1789957864578,"version":"4.0.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>We compared the diagnostic value of four neuroimaging techniques, namely, <jats:sup>123<\/jats:sup>I\u20102\u03b2\u2010Carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)\u2010N\u2010(3\u2010fluoropropyl) nortropane (<jats:sup>123<\/jats:sup>I\u2010FP\u2010CIT) dopamine transporter single\u2010photon emission computed tomography (DAT\u2010SPECT), magnetic resonance imaging, perfusion SPECT and <jats:sup>123<\/jats:sup>I\u2010metaiodobenzyl\u2010guanidine myocardial scintigraphy in differentiating dementia with Lewy bodies (DLB) from Alzheimer's disease (AD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 32 patients with probable AD and 32 patients with probable DLB were enrolled in the present study. For the comparison study, we used the specific binding ratio for DAT\u2010SPECT, the heart\u2010to\u2010mediastinum ratio in the delay phase for <jats:sup>123<\/jats:sup>I\u2010metaiodobenzyl\u2010guanidine myocardial scintigraphy, z\u2010scores in the medial occipital lobe for perfusion SPECT and z\u2010scores of hippocampal atrophy using a voxel\u2010based specific regional analysis system for AD for magnetic resonance imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DAT\u2010SPECT enabled more accurate differentiation of DLB from AD than other methods. <jats:sup>123<\/jats:sup>I\u2010metaiodobenzyl\u2010guanidine myocardial scintigraphy enabled more accurate differentiation of DLB from AD than magnetic resonance imaging and perfusion SPECT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In agreement with the recent consensus clinical diagnostic criteria for DLB, we confirmed that the diagnostic accuracy of DAT\u2010SPECT imaging is significantly higher than other neuroimaging techniques. <jats:bold>Geriatr Gerontol Int 2017; 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