{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T14:36:58Z","timestamp":1782484618528,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T00:00:00Z","timestamp":1469145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Aim<\/jats:title><jats:p>Elderly patients with autoimmune gastritis might have different symptoms than those of young patients. The aim of the present study was to compare presented symptoms and laboratory parameters associated with autoimmune gastritis in both old and young age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 355 patients with autoimmune gastritis were stratified into two groups: 65\u2009years or older (<jats:italic>n<\/jats:italic>\u2009=\u2009119, mean age 69.47\u2009\u00b1\u20095.027\u2009years), and under 65\u2009years (<jats:italic>n<\/jats:italic>\u2009=\u2009236, mean age 45.79\u2009\u00b1\u200910.51\u2009years). These two groups were then evaluated and compared by means of clinical symptoms, concurrent autoimmune diseases, serum gastrin, vitamin\u2009B<jats:sub>12<\/jats:sub> and chromogranin\u2009A levels, and the presence of enterochromograffin\u2010like cell hyperplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 119 older patients, 35 had dyspeptic symptoms, and 84 patients were referred for vitamin\u2009B<jats:sub>12<\/jats:sub> and\/or iron deficiency. In the younger group (<jats:italic>n<\/jats:italic>\u2009=\u2009236), there were more patients who had dyspeptic symptoms (36 <jats:italic>vs<\/jats:italic> 200, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Serum gastrin (726.68\u2009\u00b1\u2009266.183 <jats:italic>vs<\/jats:italic> 214.36\u2009\u00b1\u2009104.62\u2009pg\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and chromogranin\u2009A (301.26\u2009\u00b1\u2009172.95 <jats:italic>vs<\/jats:italic> 106.59\u2009\u00b1\u200967.66\u2009ng\/mL, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) levels were significantly higher, and the presence of enterochromograffin\u2010like cell hyperplasia was more frequent (113 <jats:italic>vs<\/jats:italic> 31, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) in older patients than younger patients. Polyautoimmunity (66.3% <jats:italic>vs<\/jats:italic> 24.5%) and multiple autoimmune syndrome (17.6% <jats:italic>vs<\/jats:italic> 5.5%) were more common in older patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There are differences in the clinical characteristics and the laboratory parameters between patients with autoimmune gastritis that are older and younger than 65\u2009years\u2010of\u2010age. Elderly patients with autoimmune gastritis were investigated more commonly for vitamin\u2009B<jats:sub>12<\/jats:sub> and\/or iron deficiency. Polyautoimmunity and multiple autoimmune syndrome were more common, and serum gastrin and chromogranin\u2009A levels were significantly higher in older patients. <jats:bold>Geriatr Gerontol Int 2017; 17: 1090\u20131095<\/jats:bold>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12832","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T09:57:24Z","timestamp":1469181444000},"page":"1090-1095","source":"Crossref","is-referenced-by-count":18,"title":["Differences between older and young patients with autoimmune gastritis"],"prefix":"10.1111","volume":"17","author":[{"given":"\u00c7a\u011fda\u015f","family":"Kalkan","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irfan","family":"Soykan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Ankara University Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.14336\/AD.2014.0500160","article-title":"Gender differences, aging and hormonal status in mucosal injury and repair","volume":"5","author":"Grishina I","year":"2014","journal-title":"Aging Dis"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2005.09.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.509"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022694"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2004.00183.x"},{"key":"e_1_2_7_7_1","first-page":"120","article-title":"Spontaneous development of organ\u2010specific autoimmune lesions in aged C57BL\/6 mice","volume":"78","author":"Hayashi Y","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711133372007"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0000000000000238"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-010-8218-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.36.2.171"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/254319"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-012-8317-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-011-0225-5"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0000000000000033"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338295"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1630007"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.9.3290"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021845"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.23.3.0466"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.049"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2007.09.025"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0047-6374(94)01532-Q"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(02)00035-0"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03324849"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-015-4021-1"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-5378.1996.tb00008.x"},{"issue":"1","key":"e_1_2_7_29_1","first-page":"1","article-title":"Factors associated with elevated serum chromogranin a levels in patients with autoimmune gastritis (Abstract in Turkish)","volume":"26","author":"Kalkan C","year":"2015","journal-title":"Turk J Gastroenterol"}],"container-title":["Geriatrics &amp; 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