{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:18:20Z","timestamp":1779887900974,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geriatrics Gerontology Int"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Evidence for the association between dialysis treatment and cognitive decline is limited. The present study aimed to determine whether dialysis treatment is associated with cognitive decline in adult outpatients of a general hospital in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional substudy of the Project in Sado for Total Health (PROST). Total Health PROST targeted adult outpatients of a general hospital in Sado City, Niigata, Japan. Among 753 patients (mean age 68.1\u00a0\u00b1\u00a011.6\u00a0years) analyzed, 66 received dialysis. Cognitive state was evaluated using the Mini\u2010Mental State Examination, and those with a Mini\u2010Mental State Examination score &lt;24 were considered \u201ccognitively declined.\u201d The prevalence of cognitive decline was compared by odds ratios calculated with multiple logistic regression analysis. Variables included in the analyses were dialysis, age, sex and self\u2010reported histories of hypertension, diabetes, stroke and ischemic heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 66 dialysis patients, 24 (36.4%) showed cognitive decline, whereas 172 (25.0%) of 687 non\u2010dialysis patients showed cognitive decline. The age and sex\u2010adjusted odds ratio for cognitive decline in dialysis patients was 2.57 (95% confidence interval 1.43\u20134.61), relative to non\u2010dialysis patients. The odds ratio remained significant (odds ratio 2.69, 95% confidence interval 1.49\u20134.88) even after adjusting for all covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of cognitive decline was high in dialysis patients relative to non\u2010dialysis patients among outpatients of a general hospital in Japan. <jats:bold>Geriatr Gerontol Int 2017; 17: 1584\u20131587.<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1111\/ggi.12937","type":"journal-article","created":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T10:04:20Z","timestamp":1479722660000},"page":"1584-1587","source":"Crossref","is-referenced-by-count":11,"title":["Association between dialysis treatment and cognitive decline: A study from the Project in Sado for Total Health (PROST), Japan"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9046-3249","authenticated-orcid":false,"given":"Yumi","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Kitamura","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazutoshi","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Division of Preventive Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Sanpei","sequence":"additional","affiliation":[{"name":"JA Niigata Koseiren Sado General Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minako","family":"Wakasugi","sequence":"additional","affiliation":[{"name":"Center for Inter\u2010organ Communication Research Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Yokoseki","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, Resource Branch for Brain Disease Research, Brain Research Institute Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Kabasawa","sequence":"additional","affiliation":[{"name":"Department of Health Promotion Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Onodera","sequence":"additional","affiliation":[{"name":"Department of Molecular Neuroscience, Resource Branch for Brain Disease Research, Brain Research Institute Niigata University  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Ikeuchi","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryozo","family":"Kuwano","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics, Brain Research Institute University of Niigata  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Momotsu","sequence":"additional","affiliation":[{"name":"JA Niigata Koseiren Sado General Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiei","family":"Narita","sequence":"additional","affiliation":[{"name":"Division of Clinical Nephrology and Rheumatology Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Endo","sequence":"additional","affiliation":[{"name":"Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine Niigata University Graduate School of Medical and Dental Sciences  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60687-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12378"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2015.5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_7_6_1","unstructured":"Ministry of Health Labor and Welfare (JP).The New Orange Plan [Internet].2015Jan [cited 2016 Feb 1]. 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